Author

J. Ast

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:mouse· 4 Organism:human· 3 Research Focus:cell-cell communication· 2 Assay:imaging· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. Broichhagen· 4 shared B. Jones· 2 shared B. Mathes· 2 shared D. Hodson· 2 shared D. J. Hodson· 2 shared E. D'Este· 2 shared A. Arvaniti· 1 shared A. Bacon· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersPhysiology

J. Broichhagen

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Author profile →

5 papers

Recent·Most cited

Selective accumulation of matrix proteins inside of peroxisomal subdomains

J. Ast, N. Bäcker, D. Martorana, C. Renicke, T. Stehlik, T. Heimerl, C. Taxis, G. Bange, M. Bölker, B. Sandrock, K. Schink, J. Freitag

The paper identifies a peptide motif that drives peroxisomal subdomain formation in fungi and shows this mechanism is conserved in mammalian peroxisomes and mitochondria.

bioRxiv · Oct 2, 2022 · PreprintCell Biology

14-3-3ζ constrains insulin secretion by regulating mitochondrial function in pancreatic β-cells

Y. Mugabo, C. Zhao, J. J. Tan, A. Ghosh, S. A. Campbell, E. Fadzeyeva, F. Pare, S. S. Pan, M. Galipeau, J. Ast, J. Broichhagen, D. J. Hodson, E. E. Mulvihill, S. Petropoulos, G. E. Lim

This study shows that 14-3-3ζ regulates insulin secretion in pancreatic β-cells by enhancing mitochondrial function and ATP synthesis, with implications for diabetes.

bioRxiv · Oct 17, 2021Physiology

Sulfonated rhodamines as impermeable labelling substrates for cell surface protein visualization

R. Birke, J. Ast, D. A. Roosen, B. Mathes, K. Rossmann, C. Huhn, B. Jones, M. Lehmann, V. Haucke, D. Hodson, J. Broichhagen

The paper introduces sulfonated rhodamines as impermeable dyes for cell surface protein labeling, validated in live cell imaging and STED nanoscopy.

bioRxiv · Mar 16, 2021 · PreprintBiochemistry

Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates

P. Poc, V. A. Gutzeit, J. Ast, J. Lee, B. Jones, E. D'Este, B. Mathes, D. Hodson, J. Levitz, J. Broichhagen

The paper introduces SBG-conjugated fluorophores to improve extracellular labeling of SNAP-fused proteins, enabling precise analysis of GPCR populations in living cells and tissues.

bioRxiv · Jan 29, 2020Physiology

LUXendins reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

J. Ast, A. Arvaniti, N. H. F. Fine, D. Nasteska, F. B. Ashford, Z. Stamataki, Z. Koszegi, A. Bacon, S. Trapp, B. J. Jones, B. Hastoy, A. Tomas, C. Reissaus, A. K. Linnemann, E. D'Este, , D. J. Hodson

The paper introduces LUXendin peptides that label and visualize endogenous GLP1R with high specificity, revealing receptor organization and dynamics.

bioRxiv · May 8, 2019Cell Biology