Analysis of cancer genomic amplifications identifies druggable collateral dependencies within the amplicon
G. Pons, G. Gallo-Oller, N. Navarro, P. Zarzosa, J. Sansa-Girona, L. Garcia-Gilabert, A. Magdaleno, M. F. Segura, J. Sanchez de Toledo, S. Gallego, L. Moreno, J. Roma
The paper identifies druggable collateral dependencies in cancer genomic amplifications using CRISPR/Cas9 screens and integrates gene dependency with druggability and subcellular location data.
bioRxiv · Nov 16, 2022Cancer Biology