PITAR, a DNA damage-inducible Cancer/Testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA
S. Jana, M. Mondal, S. Mahale, B. Gupta, K. R. Prasasvi, L. Kandasami, N. Jha, A. Chowdhury, V. Santosh, C. Kanduri, K. Somasundaram
This paper identifies PITAR, a long noncoding RNA that inactivates p53 by stabilizing TRIM28 mRNA, and shows its role in glioblastoma progression and resistance to chemotherapy.
bioRxiv · Apr 11, 2023Cancer Biology