Terminal differentiation of villus-tip enterocytes is governed by distinct members of Tgfβ superfamily
L. Berkova, H. Fazilaty, Q. Yang, J. Kubovciak, M. Stastna, D. Hrckulak, M. Vojtechova, M. D. Brugger, G. Hausmann, P. Liberali, V. Korinek, K. Basler, T. Valenta
This study identifies distinct roles of Bmp2 and Tgfβ in driving specific enterocytic programs at different villus regions, with Bmp2 promoting terminal differentiation at the villus-tip.
bioRxiv · Nov 11, 2022Cell Biology