Author

V. Korinek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. Hrckulak· 3 shared M. Vojtechova· 3 shared T. M. Underhill· 3 shared A. Chenery· 2 shared C. Zaph· 2 shared E. Sloncova· 2 shared F. Antignano· 2 shared J. Kubovciak· 2 shared

Activity by Year

2016-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCancer Biology

D. Hrckulak

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Terminal differentiation of villus-tip enterocytes is governed by distinct members of Tgfβ superfamily

L. Berkova, H. Fazilaty, Q. Yang, J. Kubovciak, M. Stastna, D. Hrckulak, M. Vojtechova, M. D. Brugger, G. Hausmann, P. Liberali, V. Korinek, K. Basler, T. Valenta

This study identifies distinct roles of Bmp2 and Tgfβ in driving specific enterocytic programs at different villus regions, with Bmp2 promoting terminal differentiation at the villus-tip.

bioRxiv · Nov 11, 2022Cell Biology

TROP2 represents a negative prognostic factor in colorectal adenocarcinoma and its expression is associated with features of epithelial-mesenchymal transition and invasiveness

J. Svec, M. Stastna, L. Janeckova, D. Hrckulak, M. Vojtechova, J. Onhajzer, V. Kriz, K. Galuskova, E. Sloncova, J. Kubovciak, L. Pfeiferova, J. Hrudka, R. Matej, P. Waldauf, L. Havluj, , V. Korinek

This study shows TROP2 is a negative prognostic factor in colorectal cancer, linked to metastasis and poor differentiation, and suggests it could be a therapeutic target.

bioRxiv · Jul 27, 2022Cancer Biology

Tumor suppressor Hypermethylated in Cancer 1 represses expression of cell cycle regulator E2F7 in human primary cells

L. Lanikova, J. Svec, L. Janeckova, V. Pospichalova, N. Dibus, M. Vojtechova, D. Hrckulak, E. Sloncova, H. Strnad, V. Korinek

This study shows that HIC1 represses E2F7, leading to altered cell cycle progression and DNA repair in CRC, with E2F7 levels linked to patient prognosis.

bioRxiv · Jul 25, 2022 · PreprintCancer Biology

Pathogenic potential of Hic1 expressing cardiac stromal progenitors

H. Soliman, B. Paylor, W. Scott, D. Lemos, C. Chang, M. Arostegui, M. Low, C. Lee, D. Fiore, P. Braghetta, V. Pospichalova, C. E. Barkauskas, V. Korinek, A. Rampazzo, K. MacLeod, , F. Rossi

This study identifies cardiac stromal progenitors as multipotent cells that contribute to fibrosis and arrhythmogenic cardiomyopathy under different pathological conditions.

bioRxiv · Feb 12, 2019Cell Biology

HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis

K. Burrows, F. Antignano, A. Chenery, V. Korinek, T. M. Underhill, C. Zaph

This study identifies HIC1 as a retinoic acid-dependent transcriptional repressor that regulates group 3 innate lymphoid cell function and intestinal immunity.

bioRxiv · Feb 13, 2017Immunology

The transcriptional repressor HIC1 regulates intestinal immune homeostasis

K. Burrows, F. Antignano, M. Bramhall, A. Chenery, S. Scheer, V. Korinek, T. M. Underhill, C. Zaph

This study identifies HIC1 as a key regulator of intestinal immune homeostasis, showing its role in T cell function and inflammation.

bioRxiv · Oct 28, 2016Immunology