P. Liberali

The G1/S transition in mammalian stem cells in vivo is autonomously regulated by cell size

This study shows that cell size autonomously regulates the G1/S transition in mammalian epidermal stem cells, independent of extracellular signals.

Dynamics and plasticity of stem cells in the regenerating human colonic epithelium

This study develops a model to culture human intestinal organoids and identifies two stem cell states crucial for regeneration and lineage balance.

An integrated transcriptomic cell atlas of human endoderm-derived organoids

This paper creates a human endoderm organoid cell atlas by integrating single-cell transcriptomes from multiple organoid types to compare cell states with primary tissues and disease models.

Terminal differentiation of villus-tip enterocytes is governed by distinct members of Tgfβ superfamily

This study identifies distinct roles of Bmp2 and Tgfβ in driving specific enterocytic programs at different villus regions, with Bmp2 promoting terminal differentiation at the villus-tip.

Anthrax intoxication reveals that ER-Golgi membrane contact sites control the formation of plasma membrane lipid nanodomains

This study identifies TMED2 and TMED10 as essential for anthrax toxin oligomerization by controlling lipid nanodomain formation at ER-Golgi contact sites.

Multiscale light-sheet organoid imaging framework

This paper introduces a framework for long-term live-imaging of intestinal organoids using light-sheet microscopy and deep learning, enabling 3D segmentation and visualization of cellular dynamics.

Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity

This study shows that epithelial Gpr35 maintains goblet cell function and mucosal barrier integrity, protecting against Citrobacter rodentium infection.