Author

T. Niki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Microbiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

H. Arai· 2 shared K. Mukai· 2 shared T. Taguchi· 2 shared A. B. van Spriel· 1 shared A. Cambi· 1 shared A. Gala· 1 shared A. Gyampoh· 1 shared A. Makino· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

H. Arai

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A non-toxic equinatoxin-II reveals the dynamics of sphingomyelin in the cytosolic leaflet of the plasma membrane

T. Mori, T. Niki, Y. Uchida, K. Mukai, Y. Kuchitsu, T. Kishimoto, A. Makino, T. Kobayashi, H. Arai, Y. Yokoata, T. Taguchi, K. G. N. Suzuki

The paper uses a non-toxic SM probe to show dynamic SM and cholesterol domains in the cytosolic leaflet of plasma membranes.

bioRxiv · Nov 10, 2023 · PreprintCell Biology

Galectin-9 has non-apoptotic cytotoxic activity towards Acute Myeloid Leukemia independent of cytarabine resistance

G. Choukrani, N. Visser, N. Ustyanovska Avtenyuk, M. Olthuis, G. Marsman, E. Ammatuna, H. J. Lourens, T. Niki, G. Huls, E. Bremer, V. R. Wiersma

This study shows Galectin-9 induces non-apoptotic cytotoxicity in AML cells, including resistant ones, and enhances the effect of Azacytidine.

bioRxiv · Jan 12, 2023Cancer Biology

Human Galectin-9 Promotes the Expansion of HIV Reservoirs in vivo in Humanized Mice

Z. Yuan, L. B. Giron, C. Hart, A. Gyampoh, J. Koshy, K. Y. Hong, T. Niki, T. A. Premeaux, L. C. Ndhlovu, L. J. Montaner, M. Abdel-Mohsen

This study shows that Gal-9 treatment during ART increases HIV DNA and RNA in tissues of humanized mice, suggesting it promotes HIV persistence.

bioRxiv · Jul 19, 2022Microbiology

Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells

L. Du, M. S. Bouzidi, A. Gala, F. Deiter, J.-N. Billaud, S. Yeung, P. Dabral, J. Jin, G. Simmons, Z. Dossani, T. Niki, L. Ndhlovu, J. Greenland, S. K. Pillai

This study shows that galectin-9 enhances SARS-CoV-2 replication and inflammation in airway epithelial cells by promoting viral entry and activating pro-inflammatory pathways.

bioRxiv · Mar 18, 2022Microbiology

Implications of cholesterol and sphingomyelin in STING phosphorylation by TBK1

K. Takahashi, T. Niki, E. Ogawa, K. Fumika, Y. Nishioka, M. Sawa, H. Arai, K. Mukai, T. Taguchi

The paper shows that cholesterol and sphingomyelin are required for TBK1-mediated phosphorylation of STING at the TGN, mirroring in vivo conditions.

bioRxiv · Mar 15, 2021Cell Biology

Intracellular Galectin-9 controls dendritic cell function by maintaining plasma membrane rigidity

L. Querol Cano, O. Tagit, A. van Duffelen, S. Dieltjes, S. I. Buschow, T. Niki, M. Hirashima, B. Joosten, K. van den Dries, A. Cambi, C. G. Figdor, A. B. van Spriel

This study identifies intracellular Galectin-9 as essential for maintaining plasma membrane rigidity in dendritic cells, which is critical for pathogen uptake.

bioRxiv · Aug 20, 2019Cell Biology