Author

W. D. Rawlinson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Kelleher· 3 shared G. J. Walker· 3 shared R. A. Bull· 3 shared S. G. Turville· 3 shared A. Aggarwal· 2 shared A. G. Stewart· 2 shared D. B. Langley· 2 shared D. Christ· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

A. Kelleher

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolution

C. S. P. Foster, G. J. Walker, T. Jean, M. Wong, L. Brassil, S. Isaacs, Y. Lu, S. G. Turville, A. Kelleher, W. D. Rawlinson

This study tracks SARS-CoV-2 evolution through 33-100 serial passages in vitro, identifying convergent mutations that may confer fitness or transmissibility advantages.

bioRxiv · Nov 2, 2023Evolutionary Biology

TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2

A. Aggarwal, C. Fichter, V. Milogiannakis, T. Ison, M. Ruiz Silva, C. Esneau, N. Bartlett, L. Burrell, S. Patel, M. Churchill, T. Angelovich, R. Parry, J. D. Sng, G. G. Neely, C. L. Moreno, , S. G. Turville

The paper shows Omicron SARS-CoV-2 lineages rely on ACE2 without TMPRSS2 complexes for entry, due to changes in the ACE2 Collectrin-Like Domain affecting TMPRSS2 activation.

bioRxiv · Sep 22, 2023 · PreprintMicrobiology

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

R. Rouet, J. Y. Henry, M. D. Johansen, M. Sobti, H. Balachandran, D. B. Langley, G. Walker, H. Lenthall, J. Jackson, S. Ubiparipovic, O. Mazigi, P. Schofield, D. L. Burnett, S. H. J. Brown, M. Martinello, , D. Christ

This paper isolates broadly neutralizing SARS-CoV-2 antibodies from convalescent patients and shows they neutralize emerging variants more effectively than existing monoclonal antibodies.

bioRxiv · Oct 19, 2022Immunology

Ageing impairs the airway epithelium defence response to SARS-CoV-2

A. Capraro, S. L. Wong, A. Adhikari, K. M. Allan, H. R. Patel, L. Zhong, M. Raftery, A. Jaffe, M. Yeang, A. Aggarwal, L. Wu, E. Pandzic, R. M. Whan, S. Turville, O. Vittorio, , S. A. Waters

This study investigates age-related differences in the nasal epithelium's response to SARS-CoV-2, finding that older adults have impaired host defense and lower viral load due to reduced host machinery expression.

bioRxiv · Apr 5, 2021 · PreprintImmunology

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

R. Rouet, O. Mazigi, G. J. Walker, D. B. Langley, M. Sobti, P. Schofield, H. Lenthall, J. Jackson, S. Ubiparipovic, J. Y. Henry, A. Abayasingam, D. Burnett, A. Kelleher, R. Brink, R. A. Bull, , D. Christ

This paper explores antibody maturation strategies to enhance the neutralization of SARS-CoV-2 using SARS-CoV-1 antibodies, finding that some variants show potent neutralization with IC50 of 160 ng/ml.

bioRxiv · Dec 14, 2020Immunology