R. Parry

TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2

The paper shows Omicron SARS-CoV-2 lineages rely on ACE2 without TMPRSS2 complexes for entry, due to changes in the ACE2 Collectrin-Like Domain affecting TMPRSS2 activation.

The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 Gamma variant

This study compares glycosylation and antigenicity of SARS-CoV-2 Wu-1 and Gamma variants, finding that an NTD mutation alters glycan site occupancy but not antibody binding.

Evidence for an aquatic origin of influenza virus and the order Articulavirales

The paper traces the evolutionary history of the Articulavirales order, identifying aquatic origins and host jumps, including a sturgeon-associated influenza virus and a new family in Cnidaria.

Increased neurovirulence of omicron BA.5 and XBB variants over BA.1 in K18-hACE2 mice and human brain organoids

This study shows that omicron BA.5 and XBB variants are more neurovirulent than BA.1 in mice and human brain organoids, leading to increased brain infection and mortality.

Oxysterols drive inflammation via GPR183 during influenza virus and SARS-CoV-2 infection

This study identifies oxysterols and GPR183 as drivers of inflammation in the lung during influenza and SARS-CoV-2 infections, showing that targeting GPR183 reduces inflammation and disease severity.

Comparative analysis of genome-encoded viral sequences reveals the evolutionary history of flavivirids (family Flaviviridae).

The paper uses genome-encoded viral sequences to reconstruct the evolutionary history of flavivirids, revealing their origin and divergence patterns across animal phyla.

Structural analysis of 3'UTRs in insect flaviviruses reveals novel determinant of sfRNA biogenesis and provides new insights into flavivirus evolution

This study analyzes 3'UTRs of insect flaviviruses to identify novel xrRNAs involved in sfRNA biogenesis and provides insights into flavivirus evolution.

Divergent influenza-like viruses of amphibians and fish support an ancient evolutionary association

The paper identifies five divergent influenza-like viruses in amphibians and fish, suggesting an ancient evolutionary association between influenza viruses and vertebrates.

Genomic structural and transcriptional variation of Oryctes rhinoceros nudivirus (OrNV) in Coconut Rhinoceros Beetle

This study analyzes genomic structural and transcriptional variation of OrNV across geographic populations to understand its genetic diversity and potential impact on virulence.

Complete genome assembly of the Wolbachia endosymbiont of the horn fly Haematobia irritans irritans: a supergroup A strain with multiple horizontally acquired cytoplasmic incompatibility genes

Density dependent enhancement effect of Wolbachia and the host RNAi response to a densovirus in Aedes cells

The paper shows Wolbachia enhances AalDNV-1 replication in Aedes cells in a density-dependent manner and reports the generation of vpiRNAs in response to DNA virus infection.

Aedes anphevirus (AeAV): an insect-specific virus distributed worldwide in Aedes aegypti mosquitoes that has complex interplays with Wolbachia and dengue virus infection in cells

This study characterizes Aedes anphevirus (AeAV), an insect-specific virus in Aedes aegypti, showing its global distribution, vertical transmission, and complex interactions with Wolbachia and dengue virus.