Author

G. M. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

H. F. Kildegaard· 3 shared L. E. Pedersen· 3 shared H. Hefzi· 2 shared J. S. Lee· 2 shared K. J. l. C. Karottki· 2 shared N. E. Lewis· 2 shared A. Thomas· 1 shared A. W. Chiang· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBioengineering

H. F. Kildegaard

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening

S. H. Kim, S. Shin, M. Baek, K. Xiong, K. J. l. C. Karottki, H. Hefzi, L. M. Grav, L. E. Pedersen, H. F. Kildegaard, N. E. Lewis, J. S. Lee, G. M. Lee

The paper identifies hyperosmotic stress-responsive genes in CHO cells using CRISPR/Cas9 screening and validates their role in stress resistance and protein production.

bioRxiv · Dec 13, 2022Bioengineering

A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes

K. J. l. C. Karottki, H. Hefzi, S. Li, L. E. Pedersen, P. Spahn, C. Joshi, D. Ruckerbauer, J. H. Bort, A. Thomas, J. S. Lee, N. Borth, G. M. Lee, H. F. Kildegaard, N. E. Lewis

The paper uses a CRISPR-Cas9 screen in Chinese hamster ovary cells to identify glutamine-sensitive genes, revealing a novel lipase involved in TCA cycle regulation.

bioRxiv · May 7, 2020Bioengineering

Multiplex secretome engineering enhances recombinant protein production and purity

S. Kol, D. Ley, T. Wulff, M. Decker, J. Arnsdorf, J. M. Gutierrez, A. W. Chiang, L. E. Pedersen, H. F. Kildegaard, G. M. Lee, N. Lewis

This study shows that deleting multiple host cell proteins in CHO cells improves recombinant protein production and purity through enhanced purification efficiency.

bioRxiv · May 24, 2019Bioengineering