Author

K. Xiong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Bioengineering· 2 Pathology· 2 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:metagenomics· 2

Frequent Co-Authors

J. Masel· 3 shared D. Porfirio· 1 shared D. Shea· 1 shared E. Nguyen· 1 shared G. Gydush· 1 shared G. M. Lee· 1 shared G. M. Makrigiorgos· 1 shared H. F. Kildegaard· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersEvolutionary Biology

J. Masel

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening

S. H. Kim, S. Shin, M. Baek, K. Xiong, K. J. l. C. Karottki, H. Hefzi, L. M. Grav, L. E. Pedersen, H. F. Kildegaard, N. E. Lewis, J. S. Lee, G. M. Lee

The paper identifies hyperosmotic stress-responsive genes in CHO cells using CRISPR/Cas9 screening and validates their role in stress resistance and protein production.

bioRxiv · Dec 13, 2022Bioengineering

CODEC enables 'single duplex' sequencing

J. H. Bae, R. Liu, E. Nguyen, J. Rhoades, T. Blewett, K. Xiong, D. Shea, G. Gydush, S. Tabrizi, Z. An, S. Patel, G. M. Makrigiorgos, T. R. Golub, V. A. Adalsteinsson

CODEC improves mutation detection by combining NGS throughput with single-molecule resolution, achieving similar accuracy with fewer reads.

bioRxiv · Jun 11, 2021Bioengineering

Differences in evolutionary accessibility determine which equally effective regulatory motif evolves to generate pulses

K. Xiong, M. Gerstein, J. Masel

The paper shows that evolutionary accessibility, not just functionality, determines which regulatory motif evolves to generate protein pulses, with I1FFLs being more accessible under most conditions.

bioRxiv · Dec 2, 2020Evolutionary Biology

Association between ocular biometrical parameters and diabetic retinopathy in Chinese adults with type 2 diabetes mellitus

L. Wang, S. Liu, W. Wang, M. He, Z. Mo, X. Gong, K. Xiong, Y. Li, W. Huang

This study examines the relationship between ocular biometrical parameters and diabetic retinopathy in Chinese adults with type 2 diabetes, finding associations between axial length, lens power, and AL/CR ratio with DR risk.

bioRxiv · Feb 6, 2020Pathology

High transcriptional error rates vary as a function of gene expression level

K. M. Meer, P. G. Nelson, K. Xiong, J. Masel

The paper examines transcriptional error rates in E. coli and S. cerevisiae, finding a relationship between gene expression levels and error rates for non-CU errors in E. coli but not in S. cerevisiae.

bioRxiv · Oct 26, 2019Evolutionary Biology

The effect of heavy metal contamination on human and animal health in the vicinity of a zinc smelter

X. Shen, Y. Chi, K. Xiong

This study measures heavy metal levels in soil, water, forages, and tissues of sheep and humans near a zinc smelter, finding elevated cadmium and lead concentrations linked to health risks.

bioRxiv · Nov 1, 2018Ecology

β-lactam Antibiotics Stimulate the Pathogenicity of Methicillin-resistant Staphylococcus aureus Via SarA-controlled Tandem Lipoprotein Expression

W. Shang, Y. Rao, Y. Zheng, Y. Yang, Q. Hu, Z. Hu, J. Yuan, H. Peng, K. Xiong, L. Tan, S. Li, J. Zhu, M. Li, X. Hu, X. Mao, X. Rao

This study shows that β-lactam antibiotics increase MRSA pathogenicity by upregulating the tlpps gene cluster via SarA, leading to enhanced inflammation and infection severity.

bioRxiv · Jun 21, 2018Pathology

Drift barriers to quality control when genes are expressed at different levels

K. Xiong, J. P. McEntee, D. Porfirio, J. Masel

The paper shows that population size affects the evolution of gene expression error control strategies, with smaller populations favoring global error reduction and larger populations allowing for more localized error tolerance.

Genetics · Jan 1, 2017Peer-reviewedEvolutionary Biology