Author

H. G. Garcia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Plant Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Assay:imaging· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2

Frequent Co-Authors

S. Alamos· 4 shared N. C. Lammers· 3 shared Y. J. Kim· 3 shared J. Liu· 2 shared K. K. Niyogi· 2 shared M. A. Turner· 2 shared A. Flamholz· 1 shared A. Reimer· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersBiophysics

S. Alamos

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Optogenetic dissection of transcriptional repression in a multicellular organism

J. Zhao, N. C. Lammers, S. Alamos, Y. J. Kim, G. Martini, H. G. Garcia

This study uses optogenetics and mathematical modeling to show that the zinc-finger repressor Knirps rapidly and memorylessly represses gene expression by reducing transcriptional burst frequency.

Nature Communications · Oct 26, 2024Peer-reviewedBiophysics

Flexibility and sensitivity in gene regulation out of equilibrium

S. Mahdavi, G. L. Salmon, P. Daghlian, H. G. Garcia, R. Phillips

This paper investigates how energy dissipation in gene regulatory networks enables nonmonotonic and sensitive gene expression behaviors not achievable at equilibrium.

bioRxiv · Apr 11, 2023Biophysics

Decoding of YAP levels and dynamics by pluripotency factors

K. Meyer, N. C. Lammers, L. J. Bugaj, H. G. Garcia, O. D. Weiner

The paper investigates how YAP activation levels and dynamics regulate pluripotency factors Oct4 and Nanog through differential thresholds and adaptive transcriptional responses.

bioRxiv · Oct 17, 2022 · PreprintCell Biology

Competing constraints shape the non-equilibrium limits of cellular decision making

N. C. Lammers, A. Flamholz, H. G. Garcia

The paper investigates how energy dissipation in eukaryotic transcriptional cycles affects gene information transmission and decision-making under varying levels of transcription factor interference.

bioRxiv · Jul 1, 2022 · PreprintBiophysics

Chromatin changes in PIF-regulated genes parallel their rapid transcriptional response to light

E. Gonzalez-Grandio, S. Alamos, Y. Zhang, J. Dalton-Roesler, K. K. Niyogi, H. G. Garcia, P. H. Quail

The paper identifies light-responsive genes regulated by PIF and shows that chromatin changes, specifically H3K9 acetylation, parallel rapid transcriptional responses to light.

bioRxiv · Oct 4, 2021 · PreprintPlant Biology

Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer

Y. J. Kim, K. Rhee, J. Liu, P. Jeammet, M. A. Turner, S. Small, H. G. Garcia

The paper uses thermodynamic models to show that higher-order cooperativity between transcription factors drives transcriptional repression in a synthetic enhancer.

bioRxiv · Jul 28, 2021Biophysics

Quantitative imaging of RNA polymerase II activity in plants reveals the single-cell basis of tissue-wide transcriptional dynamics

S. Alamos, A. Reimer, K. K. Niyogi, H. G. Garcia

This study uses live-imaging to quantify RNA polymerase II activity in plant cells, revealing that transcriptional responses to stress involve changes in cell engagement rather than transcription rate.

bioRxiv · Aug 30, 2020Plant Biology

Real-time single-cell characterizationof the eukaryotic transcription cyclereveals correlations between RNAinitiation, elongation, and cleavage

J. Liu, D. Hansen, E. Eck, Y. J. Kim, M. A. Turner, S. Alamos, H. G. Garcia

This study uses Bayesian inference to analyze real-time single-cell transcription dynamics in fruit flies, revealing correlations between RNA initiation, elongation, and cleavage.

bioRxiv · Aug 29, 2020 · PreprintBiophysics