Compromised nuclear envelope integrity drives tumor cell invasion
G. Nader, S. Aguera-Gonzalez, F. Routet, M. Gratia, M. Maurin, V. Cancila, C. Cadart, M. Gentili, A. Yamada, C. Lodillinsky, E. Lagoutte, C. Villard, J.-L. Viovy, C. Tripodo, G. Scita, , M. Piel
The paper shows that mechanical nuclear envelope ruptures in cancer cells cause DNA damage and promote invasion through ATM activation and TREX1 depletion.
bioRxiv · May 22, 2020Cell Biology