N. Srivastava

Anopheles salivary apyrase regulates blood meal hemostasis and drives malaria parasite transmission

This study shows that Anopheles salivary apyrase promotes Plasmodium transmission by modulating hemostasis during blood feeding.

Tension sensing by FAK governs nuclear mechanotransduction, endothelial transcriptome and fate

This study shows that FAK-mediated tension sensing in endothelial cells regulates nuclear mechanotransduction, transcriptome, and cell fate, crucial for maintaining a restrictive endothelial barrier.

Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

This study shows caveolin-1 reduces TEM tunnel size by stiffening the membrane, and its depletion increases TEM number and size, leading to higher lethality in mice during infection.

Genetic instability from a single S-phase after whole genome duplication

This study shows that newly formed tetraploid human cells experience high DNA damage during the first S-phase, leading to abnormal karyotypes and genetic instability.

A mechano-osmotic feedback couples cell volume to the rate of cell deformation

The paper shows that cell volume depends on the rate of deformation, proposing a mechano-osmotic coupling model involving actin cortex and ion fluxes.

Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment

This study shows that pan-SHIP1/2 inhibition prevents diet-induced obesity and improves glucose regulation, but requires eosinophils for fat reduction and acts via the VAT immune compartment.

Kinome Profiling of Primary Endometrial Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies SRPK1 As Candidate Therapeutic Target

The paper develops a SILAC-based MIB-MS workflow to profile the kinome in endometrial tumors, identifying SRPK1 as a potential therapeutic target.

The nucleus acts as a ruler tailoring cell responses to spatial constraints

The paper shows that the nucleus acts as a ruler by triggering contractile responses when confined, influencing cell migration and processes like cancer invasion and immune responses.

Targeting AGTR1/NF-κB /CXCR4 axis by miR-155 attenuates oncogenesis in Glioblastoma

This study shows miR-155 targets AGTR1's 3UTR, reduces AGTR1-mediated oncogenic processes, and suppresses tumor growth in GBM models.

The Piezo channel is used by migrating cells to sense compressive load

This study shows that migrating Dictyostelium cells use the Piezo channel to sense compressive force, leading to calcium influx and bleb-based motility.

Probing the effect of uniaxial compression on cell migration

This study investigates how uniaxial compression affects cell migration in Dictyostelium, showing a rapid transition from pseudopodial to bleb-driven migration under mechanical stress.