M. Gentili

The HLA-II immunopeptidome of SARS-CoV-2

The paper identifies SARS-CoV-2 peptides presented by HLA-II complexes, showing their association with CD4+ T cell epitopes and distinct targeting of viral proteins compared to HLA-I.

ESCRT-dependent STING degradation curtails steady-state and cGAMP-induced signaling

The paper identifies an ESCRT complex that degrades STING to suppress its signaling, showing its role in maintaining immune homeostasis.

Induction of transposable element expression is central to innate sensing

The paper shows that exogenous PAMPs epigenetically activate LINE1 TEs, which engage cGAS to enhance innate immune responses.

An efficient lentiviral CRISPRi approach to silence genes in primary human monocytes

This paper develops a lentiviral CRISPRi system to silence genes in primary human monocytes and demonstrates its use in studying gene function.

A cell-free antibody engineering platform rapidly generates SARS-CoV-2 neutralizing antibodies

This paper introduces CeVICA, a cell-free platform for generating SARS-CoV-2 neutralizing antibodies, identifying over 800 binder families and 6 effective inhibitors.

SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs

The paper identifies HLA-I peptides from SARS-CoV-2 in infected cells, revealing epitopes from both canonical and out-of-frame ORFs, which could inform vaccine development.

Compromised nuclear envelope integrity drives tumor cell invasion

The paper shows that mechanical nuclear envelope ruptures in cancer cells cause DNA damage and promote invasion through ATM activation and TREX1 depletion.