Author

G. Padalino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Zoology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 1

Frequent Co-Authors

A. Brancale· 2 shared K. F. Hoffmann· 2 shared A. Coghlan· 1 shared B. Hulme· 1 shared C. A. Celatka· 1 shared C. Grunau· 1 shared C. Paz· 1 shared D. Lassalle· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

A. Brancale

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Author profile →

3 papers

Recent·Most cited

Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) is a druggable target involved in parasite survival, oviposition and stem cell proliferation.

G. Padalino, C. A. Celatka, H. Y. Rienhoff, J. H. Kalin, P. A. Cole, D. Lassalle, C. Grunau, I. W. Chalmers, A. Brancale, K. F. Hoffmann

This study investigates the anti-schistosomal activity of HsLSD1 inhibitors on S. mansoni life cycle stages and identifies compound 33 as effective against parasite survival, oviposition, and stem cell proliferation.

bioRxiv · Sep 17, 2020 · PreprintMicrobiology

Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni

J. Wang, C. Paz, G. Padalino, A. Coghlan, Z. Lu, I. Gradinaru, J. N. R. Collins, M. Berriman, K. F. Hoffman, J. Collins

This study performs a large-scale RNAi screen in Schistosoma mansoni to identify therapeutic targets, finding genes involved in neuromuscular function, tissue integrity, and parasite survival.

bioRxiv · Feb 5, 2020 · PreprintMicrobiology

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

K. Whatley, G. Padalino, H. Whiteland, K. Geyer, B. Hulme, I. Chalmers, J. Forde-Thomas, S. Ferla, A. Brancale, K. F. Hoffmann

This paper screens epigenetic probes/inhibitors against Schistosoma mansoni and identifies compounds targeting histone methylation/demethylation processes as potential anti-schistosomal agents.

bioRxiv · Aug 8, 2019Zoology