Author

K. F. Hoffmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Pharmacology & Toxicology· 2 Zoology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 6 Approach:experimental assay· 6 Organism:human· 4 Assay:metabolomics· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Brancale· 3 shared G. Padalino· 3 shared H. Whiteland· 3 shared J. Forde-Thomas· 2 shared K. Whatley· 2 shared L. Mur· 2 shared A. Coghlan· 1 shared A. Crusco· 1 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

A. Brancale

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

2,3-bis (phenylamino) quinoxaline - containing compounds display potent activity against Methicillin-resistant Staphylococcus aureus, Enterococcus faecalis and their biofilms

G. Padalino, K. Duggan, L. Mur, J.-Y. Millard, A. Brancale, K. F. Hoffmann

This study identifies two quinoxaline derivatives with potent antibacterial activity against MRSA, VRE, and their biofilms, showing comparable or better efficacy than existing antibiotics.

bioRxiv · Jul 15, 2024 · PreprintMicrobiology

Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites - Trichuris muris, Brugia malayi, Heligmosomoides polygyrus and Schistosoma mansoni

F. A. Partridge, C. J. Bataille, R. Forman, A. E. Marriott, J. Forde-Thomas, C. Häberli, R. L. Dinsdale, J. D. O'Sullivan, N. J. Willis, G. M. Wynne, H. Whiteland, J. Archer, A. Steven, J. D. Turner, J. Keiser, , D. B. Sattelle

The paper investigates the structure-activity relationship of dihydrobenzoxazepinone (DHB) compounds against various parasitic nematodes and trematodes, identifying key structural features for anthelmintic activity.

bioRxiv · Nov 17, 2020Pharmacology & Toxicology

The anti-mycobacterial activity of Artemisia annua L is based on deoxyartemisinin and artemisinic acid

S. Bhowmick, R. Baptista, D. Fazakerley, K. Whatley, K. F. Hoffmann, J. Shen, L. Mur

This study identifies deoxyartemisinin and artemisinic acid from Artemisia annua as active against Mycobacterium smegmatis, with artemisinic acid showing the highest efficacy.

bioRxiv · Oct 23, 2020 · PreprintPharmacology & Toxicology

Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) is a druggable target involved in parasite survival, oviposition and stem cell proliferation.

G. Padalino, C. A. Celatka, H. Y. Rienhoff, J. H. Kalin, P. A. Cole, D. Lassalle, C. Grunau, I. W. Chalmers, A. Brancale, K. F. Hoffmann

This study investigates the anti-schistosomal activity of HsLSD1 inhibitors on S. mansoni life cycle stages and identifies compound 33 as effective against parasite survival, oviposition, and stem cell proliferation.

bioRxiv · Sep 17, 2020 · PreprintMicrobiology

Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal.

H. Whiteland, A. Crusco, J. Tibble-Howlings, J. Forde Thomas, L. W. Bloemberg, A. Coghlan, P. Murphy, K. F. Hoffmann

This study identifies N-acyl homoserine lactones as a new class of anti-schistosomal compounds with activity against all schistosome lifecycle stages and some antimicrobial effects against Gram+ and Gram- bacteria.

bioRxiv · Jul 24, 2020Zoology

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

K. Whatley, G. Padalino, H. Whiteland, K. Geyer, B. Hulme, I. Chalmers, J. Forde-Thomas, S. Ferla, A. Brancale, K. F. Hoffmann

This paper screens epigenetic probes/inhibitors against Schistosoma mansoni and identifies compounds targeting histone methylation/demethylation processes as potential anti-schistosomal agents.

bioRxiv · Aug 8, 2019Zoology