Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity
R. L. S. Goncalves, Z. B. Wang, K. E. Inouye, Y. G. Lee, X. Fu, J. Saksi, C. Rosique, G. Parlakgul, A. P. Arruda, T. S. Hui, M. C. Loperena, S. C. Burgess, I. Graupera, G. S. Hotamisligil
The paper shows that ubiquinone deficiency in obesity leads to reverse electron transport, increasing mROS and disrupting hepatic metabolic homeostasis.
bioRxiv · Feb 21, 2023 · PreprintBiochemistry