Author

G. Piedrafita

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

A. Herms· 3 shared B. Colom· 3 shared D. Fernandez-Antoran· 3 shared K. Murai· 3 shared P. H. Jones· 3 shared S. H. Ong· 2 shared A. Kalogeropoulou· 1 shared A. R. Lowe· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCell Biology

A. Herms

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Epithelioids: Self-sustaining 3D epithelial cultures to study long-term processes

A. Herms, D. Fernandez-Antoran, M. Alcolea, A. Kalogeropoulou, U. Banerjee, G. Piedrafita, E. Abby, J. A. Valverde-Lopez, I. S. Ferreira, S. Dentro, S. H. Ong, B. Colom, K. Murai, C. King, K. T. Mahbubani, , P. H. Jones

This paper introduces epithelioids, a 3D culture system for mouse and human epithelia that maintains structure and function over long periods, enabling study of long-term biological processes.

bioRxiv · Jan 3, 2023Cell Biology

Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic PIK3CA mutant progenitors in the esophagus

A. Herms, B. Colom, G. Piedrafita, K. Murai, S. H. Ong, D. Fernandez-Antoran, C. Bryant, C. Frezza, B. Vanhaesebroeck, P. H. Jones

The paper shows that reducing aerobic glycolysis differences between mutant and wild-type cells limits the competitive advantage of PIK3CA mutant progenitors in the esophagus.

bioRxiv · May 28, 2021Cancer Biology

Single amino acid-promoted reactions link a non-enzymatic chemical network to the early evolution of enzymatic pentose phosphate pathway

G. Piedrafita, S. J. Varma, C. Castro, C. B. Messner, L. Szyrwiel, J. L. Griffin, M. Ralser

This paper shows how single amino acids can enhance non-enzymatic reactions similar to the pentose phosphate pathway, suggesting a stepwise evolution from environmental chemical networks to enzymatic metabolism.

bioRxiv · Aug 11, 2020Biochemistry

The single-progenitor model as the unifying paradigm of squamous epithelial maintenance

G. Piedrafita, V. Kostiou, A. Wabik, B. Colom, D. Fernandez-Antoran, A. Herms, K. Murai, B. A. Hall, P. H. Jones

This study uses lineage tracing and proliferation assays to show that squamous epithelial tissues are maintained by a single population of proliferating cells, not multiple stem cell types.

bioRxiv · Jul 26, 2019Cell Biology