Author

G. Piszczek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 5 Research Focus:host-pathogen & immune response· 3 Organism:virus· 3 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. Wu· 7 shared A. Nguyen· 4 shared H. Zhao· 4 shared P. Schuck· 4 shared D. N. Nguyen· 2 shared G. Beaudoin-Bussieres· 2 shared I. Ullah· 2 shared J. Chen· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

7 shared papersBiophysics

D. Wu

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Assembly reactions of SARS-CoV-2 nucleocapsid protein with nucleic acid

H. Zhao, A. M. Syed, M. M. Khalid, A. Nguyen, A. Ciling, D. Wu, W.-M. Yau, S. Srinivasan, D. Esposito, J. A. Doudna, G. Piszczek, M. Ott, P. Schuck

This study investigates the assembly of SARS-CoV-2 nucleocapsid protein with nucleic acids using biophysical techniques and mutant proteins, revealing key interaction motifs and stabilization mechanisms.

bioRxiv · Nov 22, 2023 · PreprintBiophysics

Modulation of Biophysical Properties of Nucleocapsid Protein in the Mutant Spectrum of SARS-CoV-2

A. Nguyen, H. Zhao, D. Myagmarsuren, S. Srinivasan, D. Wu, J. Chen, G. Piszczek, P. Schuck

The paper examines how mutations in SARS-CoV-2 nucleocapsid protein's intrinsically disordered regions affect its biophysical properties across different variants.

bioRxiv · Nov 21, 2023Biophysics

Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain

Y. Chen, J. Prevost, I. Ullah, H. Romero, V. Lisi, W. D. Tolbert, J. R. Grover, S. Ding, S. Y. Gong, G. Beaudoin-Bussieres, R. Gasser, M. Benlarbi, D. Vezina, S. P. Anand, D. Chatterjee, , A. Finzi

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

bioRxiv · Jul 27, 2022 · PreprintMicrobiology

Plasticity in structure and assembly of SARS-CoV-2 nucleocapsid protein

H. Zhao, A. Nguyen, D. Wu, Y. Li, S. A. Hassan, J. Chen, H. Shroff, G. Piszczek, P. Schuck

The paper analyzes sequence and structural variability in the SARS-CoV-2 nucleocapsid protein, finding high mutability and structural plasticity linked to enhanced viral assembly efficiency.

bioRxiv · Feb 8, 2022Biophysics

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities

Y. Chen, L. Sun, I. Ullah, G. Beaudoin-Bussieres, S. P. Anand, A. P. Hederman, W. D. Tolbert, R. Sherburn, D. N. Nguyen, L. Marchitto, S. Ding, D. Wu, Y. Luo, S. Gottumukkala, S. Moran, , M. Pazgier

The paper develops ACE2-Fc molecules that neutralize SARS-CoV-2 and show Fc-effector activity, effectively treating lethal infection in mice.

bioRxiv · Nov 24, 2021Microbiology

Rapid Characterization of AAV gene therapy vectors by Mass Photometry

D. Wu, P. Hwang, T. Li, G. Piszczek

This paper demonstrates that mass photometry can rapidly and accurately characterize rAAV vectors by resolving capsid populations and quantifying full and empty capsids.

bioRxiv · Feb 18, 2021Biophysics

Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids

H. Zhao, D. Wu, A. Nguyen, Y. Li, R. Adão, E. Valkov, G. H. Patterson, G. Piszczek, P. Schuck

This study investigates how SARS-CoV-2 N-protein interacts with nucleic acids to form supramolecular clusters and phase-separated droplets, revealing structural and energetic changes during assembly.

bioRxiv · Feb 8, 2021Biophysics