Author

G. Wen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Microbiology· 2 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:imputation· 4 Research Focus:drug response / drug discovery· 3 Assay:fluorescence / live-cell microscopy· 3 Organism:mouse· 3 Approach:microscopy & imaging analysis· 2 Research Focus:spatial domain detection· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

P. Tao· 3 shared C. Chen· 2 shared C. Gu· 2 shared H. Feng· 2 shared H. Li· 2 shared J. Hofkens· 2 shared J. Zhu· 2 shared L. Wang· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

P. Tao

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Flat-field superresolution structured illumination microscopy with joint temporal-spatial light modulation

Y. Liang, G. Wen, J. Zhang, S. Li, Y. Tan, X. Jin, L. Wang, X. Chen, J. Gao, H. Li

This paper introduces a flat-field structured illumination microscopy method to improve field uniformity and enable large-scale imaging of whole cells and pathological samples.

bioRxiv · May 1, 2024 · PreprintCell Biology

Rapid Development of a Mucosal Nanoparticle Flu Vaccine by Genetic Engineering of Bacteriophage T4 using CRISPR-Cas

M. Li, C. Chen, X. Wang, P. Guo, H. Feng, X. Zhang, W. Zhang, C. Gu, J. Zhu, G. Wen, V. B. Rao, P. Tao

This study develops a mucosal nanoparticle flu vaccine using CRISPR-Cas to engineer bacteriophage T4, showing it induces both mucosal and systemic immunity in mice.

Antiviral Research · Sep 1, 2023Peer-reviewedImmunology

BacScan: An Unbiased and Genome-Wide Approach to Identify Bacterial Highly Immunogenic Proteins

P. Tao, J. Dong, Q. Zhang, J. Yang, Y. Zhao, Z. Miao, S. Pei, H. Qin, G. Wen, A. Zhang

BacScan identifies highly conserved immunogenic bacterial proteins across serotypes, showing potential for vaccine development.

bioRxiv · Jul 26, 2023Microbiology

Trifunctional linkers enable improved visualization of actin by expansion microscopy

G. Wen, M. D. Lycas, Y. Jia, V. Leen, M. Sauer, J. Hofkens

The paper introduces TRITON trifunctional linkers to improve actin visualization in expansion microscopy, achieving better signal retention and anchoring.

bioRxiv · May 10, 2023Biochemistry

Bacteriophage T4 Vaccine Platform for Next-generation Influenza Vaccine Development

M. Li, P. Guo, C. Chen, H. Feng, W. Zhang, C. Gu, G. Wen, V. B. Rao, P. Tao

This study demonstrates a T4 phage-based vaccine platform that incorporates M2e antigens, showing high immunogenicity and complete protection against influenza without adjuvants.

bioRxiv · Jun 14, 2021Microbiology

Parietal cell-Specific SLC26A9 Deletion induces spontaneous Gastric Carcinogenesis in Mice

X. Liu, T. Li, D. Yuan, B. Riederer, Z. Ma, J. Zhu, Y. Li, J. An, G. Wen, H. Jin, C. Hu, M. Zhang, X. Yang, U. Seidler, B. Tuo

This study shows that deleting Slc26a9 in parietal cells of mice leads to spontaneous gastric cancer and identifies molecular mechanisms involved in tumor progression.

bioRxiv · Sep 28, 2020 · PreprintCancer Biology

HiFi-SIM: reconstructing high-fidelity structured illumination microscope images

G. Wen, s. li, L. Wang, X. Chen, Z. Sun, Y. Liang, X. Jin, Y. Tang, H. Li

HiFi-SIM improves structured illumination microscopy image fidelity by reducing artifacts and enhancing axial resolution without requiring precise PSF calibration or parameter tuning.

bioRxiv · Jul 16, 2020 · PreprintBiophysics

Evaluation of direct grafting strategies in Expansion Microscopy

G. Wen, M. Vanheusden, A. Acke, D. Vali, S. F. Mayer, R. K. Neely, V. Leen, J. Hofkens

The paper introduces a chemical linking approach for direct grafting in expansion microscopy to improve signal preservation and enable multiplexed imaging.

bioRxiv · Jul 8, 2019 · PreprintBiophysics