Z. Miao

metaExpertPro: a computational workflow for metaproteomics spectral library construction and data-independent acquisition mass spectrometry data analysis

metaExpertPro constructs metaproteomics spectral libraries and analyzes DIA-MS data, achieving high peptide quantification and low FDR in human fecal samples.

BacScan: An Unbiased and Genome-Wide Approach to Identify Bacterial Highly Immunogenic Proteins

BacScan identifies highly conserved immunogenic bacterial proteins across serotypes, showing potential for vaccine development.

A comparison of convolutional neural networks and few-shot learning in classifying long-tailed distributed tropical bird songs

This study compares CNN and few-shot learning methods for classifying rare tropical bird songs, finding Siamese Networks perform better with limited data.

Assessment of three-dimensional RNA structure prediction in CASP15

This paper evaluates RNA 3D structure prediction methods in CASP15, finding that non-deep learning groups outperformed deep learning models, with challenges in fine details and model ranking.

An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission

This study develops an FcRn-targeted mucosal vaccine that reduces SARS-CoV-2 infection and transmission in mice and hamsters by inducing protective immune responses in the airways.

Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence

This study determines the structure of RsmZ in complex with RsmA, revealing how RsmZ regulates virulence in Pseudomonas aeruginosa by modulating RsmA binding and gene expression.

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

This study identifies chromatin remodeling factors that limit T cell persistence using CRISPR screens and shows their impact on anti-tumor immunity.

Rora regulates activated T helper cells during inflammation

This study investigates Rora's role in CD4+ T cells during inflammation, finding it regulates lung inflammation and is controlled by IL-33 and CCL7.

Longevity, clonal relationship and transcriptional program of celiac disease-specific plasma cells

The paper analyzes single-cell RNA-seq data from plasma cells in celiac disease patients to identify transcriptional differences and clonal relationships between disease-specific and non-specific plasma cells.

Efficacy of transoral laser surgery versus linear accelerator radiotherapy for the treatment of T1 glottic carcinoma: a meta-analysis of oncologic outcomes

This meta-analysis compares oncologic outcomes of T1 glottic carcinoma treated with transoral laser surgery or linear accelerator radiotherapy, finding better overall survival and laryngeal preservation with surgery.

Interpretable machine learning framework reveals novel gut microbiome features in predicting type 2 diabetes

The paper develops an interpretable machine learning framework to identify gut microbiome features predictive of type 2 diabetes, validated across multiple cohorts and linked to metabolic outcomes.

Shift of maternal gut microbiome of Tibetan antelope (Pantholops hodgsonii) during the perinatal period

This study examines changes in the gut microbiome of Tibetan antelope during the perinatal period using 16S rRNA sequencing and correlates it with hormone levels.

The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for human complex diseases

This study identifies host genetic variants associated with gut microbiome and examines causal relationships between gut microbiome and human complex diseases, revealing shared and distinct microbiome features.

Single cell transcriptomics identifies a unique adipocyte population that regulates bone marrow environment

The paper identifies a unique adipocyte population in bone marrow, MERAs, that regulate bone and vessel homeostasis through single-cell transcriptomics in mice.

A comparison of visual features used by humans and machines to classify wildlife

This paper compares visual features used by humans and machines to classify 20 African wildlife species using CNNs, showing some similarity but not complete agreement.

The IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

This study identifies XBP1 target genes and shows the IRE1a-XBP1 pathway resolves secretory stress and promotes Th2 cell proliferation and cytokine regulation.