Author

V. B. Rao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

H. Batra· 4 shared J. Zhu· 4 shared P. Tao· 4 shared S. Jain· 4 shared M. Li· 3 shared M. Mahalingam· 3 shared N. Ananthaswamy· 3 shared A. Drelich· 2 shared

Activity by Year

2021-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersMicrobiology

H. Batra

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Rapid Development of a Mucosal Nanoparticle Flu Vaccine by Genetic Engineering of Bacteriophage T4 using CRISPR-Cas

M. Li, C. Chen, X. Wang, P. Guo, H. Feng, X. Zhang, W. Zhang, C. Gu, J. Zhu, G. Wen, V. B. Rao, P. Tao

This study develops a mucosal nanoparticle flu vaccine using CRISPR-Cas to engineer bacteriophage T4, showing it induces both mucosal and systemic immunity in mice.

Antiviral Research · Sep 1, 2023Peer-reviewedImmunology

The complex roles of genomic DNA modifications of bacteriophage T4 in resistance to nuclease-based defense systems of E. coli

S. Wang, E. Sun, Y. Liu, B. Yin, X. Zhang, M. Li, Q. Huang, C. Tan, P. Qian, V. B. Rao, P. Tao

The paper investigates how genomic modifications in phage T4 DNA affect its resistance to nuclease-based defense systems in E. coli, revealing roles beyond simple DNA degradation prevention.

bioRxiv · Jun 16, 2022Microbiology

A bacteriophage-based, highly efficacious, needle and adjuvant-free, mucosal COVID-19 vaccine

J. Zhu, S. Jain, J. Sha, H. Batra, N. Ananthaswamy, P. B. Kilgore, E. Hendrix, Y. M. Hosakote, X. Wu, J. P. Olano, A. Kayode, C. L. Galindo, S. Banga, A. Drelich, V. Tat, , V. B. Rao

This paper develops a bacteriophage-based mucosal vaccine that induces strong immune responses and protects against SARS-CoV-2 and its variants without requiring needles or adjuvants.

bioRxiv · Apr 28, 2022Microbiology

Targeted Bacteriophage T4 Nanoparticles Reverse HIV-1 Latency in CD4+ Human T Cells

H. Batra, J. Zhu, S. Jain, N. Ananthaswamy, M. Mahalingam, P. Tao, C. Lange, S. Hill, C. Zhong, M. F. Kearney, H. Hu, F. Maldarelli, V. B. Rao

The paper shows that CD4-targeted bacteriophage T4 nanoparticles reactivate HIV-1 latency in CD4+ T-cells without global activation or cytokine storm.

bioRxiv · Jul 20, 2021 · PreprintImmunology

A Remarkable Genetic Shift in a Transmitted/Founder Virus Broadens Antibody Responses Against HIV-1

S. Jain, G. Uritskiy, M. Mahalingam, H. Batra, S. Chand, H. Trinh, C. Beck, W.-H. Shin, W. AlSalmi, G. Kijak, L. A. Eller, J. Kim, D. Kihara, S. Tovanabutra, G. Ferrari, , V. B. Rao

The paper identifies a genetic shift in an HIV-1 transmitted/founder virus that leads to broader antibody responses by altering the V2 domain structure.

bioRxiv · Jun 16, 2021Microbiology

Bacteriophage T4 Vaccine Platform for Next-generation Influenza Vaccine Development

M. Li, P. Guo, C. Chen, H. Feng, W. Zhang, C. Gu, G. Wen, V. B. Rao, P. Tao

This study demonstrates a T4 phage-based vaccine platform that incorporates M2e antigens, showing high immunogenicity and complete protection against influenza without adjuvants.

bioRxiv · Jun 14, 2021Microbiology

A viral genome packaging ring-ATPase is a flexibly coordinated pentamer

L. Dai, D. Singh, S. Lu, V. Kottadiel, R. Vafabakhsh, M. Mahalingam, Y. R. Chemla, T. Ha, V. B. Rao

The paper determines the composition of the bacteriophage T4 DNA packaging motor and shows that it can tolerate an inactive subunit, challenging the idea of strict coordination among motor subunits.

bioRxiv · Mar 8, 2021Biophysics

A Universal Bacteriophage T4 Nanoparticle Platform to Design Multiplex SARS-CoV-2 Vaccine Candidates by CRISPR Engineering

V. B. Rao, J. Zhu, N. Ananthaswamy, S. Jain, H. Batra, W.-C. Tang, D. A. Lewry, M. L. Richards, S. A. David, P. B. Kilgore, J. Sha, A. Drelich, C.-T. Tseng, A. K. Chopra

This paper develops a CRISPR-engineered bacteriophage T4 nanoparticle platform to create multiplex SARS-CoV-2 vaccine candidates, showing potent immune responses and protection in animal models.

bioRxiv · Jan 19, 2021Microbiology