G. Xiao

This study shows that malignant B-cell transformation requires convergence on a single oncogenic pathway, while divergent pathways can subvert transformation and are targets for new therapeutic strategies.

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

This paper identifies and characterizes a novel coronavirus (nCoV-2019) causing a human pneumonia outbreak, showing its close genetic relationship to bat coronaviruses and its use of the ACE2 receptor for cell entry.

This paper develops a lipid-specific quantum dot labeling method to track enveloped viruses, showing it preserves virus integrity and enables efficient tracking of viral infection dynamics.

The paper quantifies metabolic features in NSCLC cell lines to explore associations between metabolism and other cell-autonomous processes.

This study identifies OsCYP71D8L as a regulator of gibberellin and cytokinin homeostasis in rice, affecting growth and stress tolerance.

This study identifies two FDA-approved drugs, lacidipine and phenothrin, as Lassa virus entry inhibitors through high-throughput screening and mechanistic analysis.

This study uses a deep CNN to analyze lung cancer pathology images, identifies tumor shape features linked to survival, and develops a prognostic model validated in an independent cohort.

The paper develops and validates a nomogram prognostic model for small-cell lung cancer patients using clinical data from the National Cancer Database.

The paper constructs a lung cancer database with gene expression and clinical data from 6,700 patients and develops an open web portal for data exploration and analysis.