High resolution multi-scale profiling of embryonic germ cell-like cells derivation reveals pluripotent state transitions in humans
Sarah Stucchi, Lessly P. Sepulveda-Rincon, Camille Dion, Gaja Matassa, Alessia Valenti, Cristina Cheroni, Alessandro Vitriolo, Filippo Prazzoli, George Young, Marco Tullio Rigoli, Riccardo Nagni, Martina Ciprietti, Benedetta Muda, Zoe Heckhausen, Petra Hájková, , Harry G. Leitch
This paper establishes a defined feeder-free system to convert human PGC-like cells to pluripotent stem cells, tracking transcriptional and epigenomic transitions using multi-omic analysis.
Stem Cell Reports · Dec 19, 2025Peer-reviewedDevelopmental Biology