Suppression of YAP/TAZ molecular targets by epigenetic editing interferes with GBM growth and invasiveness
Eva Baronchelli, Silvia Ferretti, Michal Kubacki, Antonella Covino, Valerio Benedetti, Edoardo Niccolò Bellini, Serena Gea Giannelli, Mirko Luoni, Elisa Ventura, Federica Banfi, Gaia Colasante, Federica Ungaro, Vania Broccoli, Alessandro Sessa
This study introduces TES, an epigenetic silencer targeting YAP/TAZ-TEAD axis in GBM, which suppresses tumor growth and invasiveness while being safe for normal cells.
bioRxiv · Mar 15, 2026 · PreprintCancer Biology