C-terminal domain mobility underpins substrate engagement by the Chaetomium thermophilum EDEM:PDI ERAD-L checkpoint complex
Charlie J. Hitchman, Andrea Lia, Mohammed Bhogadia, Geander M. Pessoa, Gabriela N. Chirițoiu, Cristian V. A. Munteanu, Juan Ortigosa, Jorge Octavio Lannot, Simona Ghenea, Ikuo Wada, Maria De Benedictis, Gábor Tax, Yusupha Bayo, Irene Crescioli, Laura Sanna, , Pietro Roversi
The paper determines Cryo-EM structures of the EDEM:PDI complex with and without a substrate, revealing how disulfide bonds regulate conformational changes essential for substrate engagement.
bioRxiv · Jan 29, 2025 · PreprintBiochemistry