Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related multisystem neurodegenerative deficits
Ariadna Laguna, Núria Peñuelas, Marta González-Sepúlveda, Alba Nicolau, Sébastien Arthaud, Camille Guillard-Sirieix, Marina Lorente Picón, Joan Compte, Lluís Miquel-Rio, Helena Xicoy, Jiong Liu, Annabelle Parent, Thais Cuadros, Jordi Romero‐Giménez, Gemma Pujol, , Miquel Vila
This paper creates a transgenic mouse model that mimics human neuromelanin accumulation in catecholaminergic neurons, leading to age-related neurodegenerative deficits.
Nature Communications · Oct 11, 2024Peer-reviewedNeuroscience