Author

H. A. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1 Organism:yeast· 1

Frequent Co-Authors

A. Capel· 1 shared A. Gimelbrant· 1 shared A. Lin· 1 shared A. R. Subramaniam· 1 shared B. Bhattacharya· 1 shared B. N. Kholodenko· 1 shared D. Skelding· 1 shared E. Brownhill· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperEvolutionary Biology

A. Capel

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Author profile →

2 papers

Recent·Most cited

Maladaptive oxidative stress cascade drives type I interferon hyperactivity in TNF activated macrophages promoting necrosis in murine tuberculosis granulomas

E. Brownhill, S. M. Yabaji, V. Zhernovkov, O. S. Rukhlenko, K. Seidel, B. Bhattacharya, S. Chatterjee, H. A. Chen, N. Crossland, W. Bishai, B. N. Kholodenko, A. Gimelbrant, L. Kobzik, I. Kramnik

This study identifies a maladaptive oxidative stress cascade in TNF-activated macrophages that drives IFN-I hyperactivity and necrosis in murine tuberculosis granulomas, with potential therapeutic targets identified.

bioRxiv · Dec 14, 2020 · PreprintImmunology

Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect

R. Green, S. Sonal, W. Lu, L. Wang, S. F. Hart, D. Skelding, J. C. Burton, A. Capel, H. A. Chen, A. Lin, A. R. Subramaniam, J. D. Rabinowitz, W. Shou

The paper shows that nutrient-growth dysregulation in yeast leads to the evolution of a metabolic defect involving organosulfur release, which confers a fitness advantage under specific conditions.

bioRxiv · Apr 26, 2020Evolutionary Biology