Author

H. A. Flaxman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

C. M. Woo· 4 shared C.-F. Chang· 2 shared F. Kabir· 2 shared B. Budnik· 1 shared D. K. Miyamoto· 1 shared D. Lagares· 1 shared H. Han· 1 shared H.-Y. Wu· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersBiochemistry

C. M. Woo

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Author profile →

4 papers

Recent·Most cited

The Cyclimids: Degron-inspired cereblon binders for targeted protein degradation

S. Ichikawa, N. C. Payne, W. Xu, C.-F. Chang, N. Vallavoju, S. Frome, H. A. Flaxman, R. Mazitschek, C. M. Woo

This study introduces cyclimids, degrons derived from CRBN, which show improved selectivity and potency in targeted protein degradation by forming ternary complexes with CRBN and substrates.

bioRxiv · Apr 22, 2023Biochemistry

Sanglifehrin A mitigates multi-organ fibrosis in vivo by inducing secretion of the collagen chaperone cyclophilin B

H. A. Flaxman, M.-A. Chrysovergi, H. Han, F. Kabir, R. T. Lister, C.-F. Chang, K. E. Black, D. Lagares, C. M. Woo

This study identifies cyclophilin B as the target of sanglifehrin A, showing it reduces collagen synthesis in fibrotic tissues by inducing cyclophilin B secretion.

bioRxiv · Mar 9, 2023 · PreprintBiochemistry

Development of photo-lenalidomide for cellular target identification

Z. Lin, Y. Amako, F. Kabir, H. A. Flaxman, B. Budnik, C. M. Woo

This paper develops photo-lenalidomide, a modified lenalidomide probe, to identify cellular targets using chemical proteomics, revealing new targets like eIF3i.

bioRxiv · Jul 12, 2021 · PreprintBiochemistry

Discovery of a celecoxib binding site on PTGES with a cleavable chelation-assisted biotin probe

D. K. Miyamoto, H. A. Flaxman, H.-Y. Wu, J. Gao, C. M. Woo

This paper identifies a new celecoxib binding site on PTGES using a cleavable chelation-assisted biotin probe and validates it through competitive displacement and structural modeling.

bioRxiv · Sep 26, 2019Pharmacology & Toxicology