Author

C.-F. Chang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Zoology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

C. M. Woo· 2 shared H. A. Flaxman· 2 shared A. L. Gunawan· 1 shared A. M. Bertholet· 1 shared A. Stahl· 1 shared B. Wang· 1 shared D. Lagares· 1 shared F. Kabir· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

C. M. Woo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Sex change every year: A unique reproductive strategy of the stony coral, Fimbriaphyllia (Euphyllia) ancor

S. Shikina, P.-H. Tsai, Y.-L. Chiu, C.-F. Chang

The study documents annual sex change in Fimbriaphyllia ancora corals, with 70% of colonies switching sexes yearly, suggesting intrinsic factors like age or genetics drive this behavior.

bioRxiv · Dec 27, 2023 · PreprintZoology

The Cyclimids: Degron-inspired cereblon binders for targeted protein degradation

S. Ichikawa, N. C. Payne, W. Xu, C.-F. Chang, N. Vallavoju, S. Frome, H. A. Flaxman, R. Mazitschek, C. M. Woo

This study introduces cyclimids, degrons derived from CRBN, which show improved selectivity and potency in targeted protein degradation by forming ternary complexes with CRBN and substrates.

bioRxiv · Apr 22, 2023Biochemistry

Sanglifehrin A mitigates multi-organ fibrosis in vivo by inducing secretion of the collagen chaperone cyclophilin B

H. A. Flaxman, M.-A. Chrysovergi, H. Han, F. Kabir, R. T. Lister, C.-F. Chang, K. E. Black, D. Lagares, C. M. Woo

This study identifies cyclophilin B as the target of sanglifehrin A, showing it reduces collagen synthesis in fibrotic tissues by inducing cyclophilin B secretion.

bioRxiv · Mar 9, 2023 · PreprintBiochemistry

Coenzyme Q regulates UCP1 expression and thermogenesis through the integrated stress responses

C.-F. Chang, A. L. Gunawan, P.-J. H. Zushin, G. A. Timblin, A. M. Bertholet, B. Wang, K. Saijo, Y. Kirichok, A. Stahl

This study shows that CoQ deficiency in BAT activates the ISR and suppresses UCP1, yet increases whole-body metabolic rates and reduces weight gain on HFD.

bioRxiv · Mar 18, 2022 · PreprintCell Biology