Author

C. M. Woo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

H. A. Flaxman· 4 shared H.-Y. Wu· 3 shared C.-F. Chang· 2 shared F. Kabir· 2 shared Z. Lin· 2 shared A. Chernykh· 1 shared A. Pap· 1 shared B. Budnik· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiochemistry

H. A. Flaxman

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Author profile →

7 papers

Recent·Most cited

The Cyclimids: Degron-inspired cereblon binders for targeted protein degradation

S. Ichikawa, N. C. Payne, W. Xu, C.-F. Chang, N. Vallavoju, S. Frome, H. A. Flaxman, R. Mazitschek, C. M. Woo

This study introduces cyclimids, degrons derived from CRBN, which show improved selectivity and potency in targeted protein degradation by forming ternary complexes with CRBN and substrates.

bioRxiv · Apr 22, 2023Biochemistry

Sanglifehrin A mitigates multi-organ fibrosis in vivo by inducing secretion of the collagen chaperone cyclophilin B

H. A. Flaxman, M.-A. Chrysovergi, H. Han, F. Kabir, R. T. Lister, C.-F. Chang, K. E. Black, D. Lagares, C. M. Woo

This study identifies cyclophilin B as the target of sanglifehrin A, showing it reduces collagen synthesis in fibrotic tissues by inducing cyclophilin B secretion.

bioRxiv · Mar 9, 2023 · PreprintBiochemistry

Molecular and structural characterization of lenalidomide-mediated sequestration of eIF3i

Z. Lin, D. Shen, B. Yang, C. M. Woo

This study identifies the structural basis of lenalidomide-mediated eIF3i sequestration and links it to antiangiogenic effects and cellular phenotypes.

bioRxiv · Aug 3, 2022Biochemistry

Development of photo-lenalidomide for cellular target identification

Z. Lin, Y. Amako, F. Kabir, H. A. Flaxman, B. Budnik, C. M. Woo

This paper develops photo-lenalidomide, a modified lenalidomide probe, to identify cellular targets using chemical proteomics, revealing new targets like eIF3i.

bioRxiv · Jul 12, 2021 · PreprintBiochemistry

Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data

R. Kawahara, A. Chernykh, K. Alagesan, M. Bern, W. Cao, R. J. Chalkley, K. Cheng, M. S. Choo, N. Edwards, R. Goldman, M. Hoffmann, Y. Hu, Y. Huang, J. Y. Kim, D. Kletter, , Palmisano

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

bioRxiv · Mar 14, 2021 · PreprintBiochemistry

Selective protein O-GlcNAcylation in cells by a proximity-directed O-GlcNAc transferase

D. H. Ramirez, C. Aonbangkhen, H.-Y. Wu, J. A. Naftaly, S. Tang, T. R. O'Meara, C. M. Woo

This paper introduces a method to selectively induce O-GlcNAcylation on target proteins using nanobody-fused OGT, enabling precise study of O-GlcNAc modifications in cells.

bioRxiv · Nov 2, 2019Biochemistry

Discovery of a celecoxib binding site on PTGES with a cleavable chelation-assisted biotin probe

D. K. Miyamoto, H. A. Flaxman, H.-Y. Wu, J. Gao, C. M. Woo

This paper identifies a new celecoxib binding site on PTGES using a cleavable chelation-assisted biotin probe and validates it through competitive displacement and structural modeling.

bioRxiv · Sep 26, 2019Pharmacology & Toxicology