O. Kurzai

Alligamycin A, an unprecedented antifungal β-lactone spiroketal macrolide from Streptomyces iranensis

This paper identifies alligamycin A, a novel antifungal compound from Streptomyces iranensis, and demonstrates its potent antifungal activity against clinically relevant fungi.

CD56-mediated activation of human natural killer cells is triggered by Aspergillus fumigatus galactosaminogalactan

This study identifies galactosaminogalactan as the fungal ligand for CD56 on human NK cells, triggering antifungal responses and immune cell activation.

The sphingolipid inhibitor myriocin increases susceptibility of Candida auris to amphotericin B

This study shows that myriocin, a sphingolipid inhibitor, increases susceptibility of Candida auris to amphotericin B and anidulafungin, suggesting sphingolipids as a target for overcoming resistance.

Transient mitochondria dysfunction confers fungal cross-resistance between macrophages and fluconazole

This study shows that C. glabrata's mitochondrial dysfunction confers cross-resistance to antifungals and macrophages, suggesting a bet-hedging strategy.

Ex vivo Immune Profiling in Patient Blood enables Quantification of innate immune Effector Functions

The paper quantifies innate immune effector functions in patient blood after ex vivo infection, revealing altered immune responses post-cardiac surgery.

Effects of agricultural fungicide use on Aspergillus fumigatus abundance, antifungal susceptibility, and population structure

This study examines the effects of agricultural fungicide use on Aspergillus fumigatus abundance, antifungal susceptibility, and population structure, finding low resistance rates and no significant genomic impact.