tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in Aspergillus fumigatus.
A. Bruch, V. Lazarova, M. Berg, T. Krueger, S. Schaeuble, A. A. Kelani, B. Mertens, P. Lehenberger, O. Kniemeyer, S. Kaiser, G. Panagiotou, F. Gsaller, M. G. Blango
This study shows that tRNA hypomodification in Aspergillus fumigatus leads to 5-fluorocytosine resistance through premature activation of a cross-pathway control system.
bioRxiv · Feb 19, 2024 · PreprintMicrobiology