O. D. Weiner

Self-extinguishing relay waves enable homeostaticcontrol of human neutrophil swarming

The paper identifies a self-extinguishing relay wave mechanism in human neutrophils that controls swarming and recruitment levels through an NADPH-oxidase-based feedback loop.

Neutrophils actively swell to potentiate rapid migration

This study identifies regulators of chemoattractant-induced neutrophil swelling and shows that cell swelling is necessary and sufficient for enhanced migration.

Rac negative feedback links local PIP3 rate-of-change to dynamic control of neutrophil guidance

The paper investigates how Rac negative feedback modulates neutrophil guidance by linking local PIP3 rate-of-change to dynamic control of cell polarization.

Decoding of YAP levels and dynamics by pluripotency factors

The paper investigates how YAP activation levels and dynamics regulate pluripotency factors Oct4 and Nanog through differential thresholds and adaptive transcriptional responses.

Actin-driven protrusions generate rapid long-range membrane tension propagation in cells

The paper uses optogenetics and optical tweezers to show that actin-driven protrusions enable rapid, long-range membrane tension propagation, contrasting with localized force application.

Progressive enhancement of kinetic proofreading in T cell antigen discrimination from receptor activation to DAG generation

WASP integrates substrate topology and cell polarity to guide neutrophil migration

This study shows WASP integrates substrate topology and cell polarity to guide neutrophil migration by selectively polymerizing actin at the leading edge.

WAVE complex self-organization templates lamellipodial formation

The paper investigates how the WAVE complex self-organizes into linear structures to form lamellipodia, contrasting with N-WASP's spiky actin networks, and shows how curvature sensing enables cell shape regulation.

Cell confinement reveals a branched-actin independent circuit for neutrophil polarity

This study shows that neutrophils can maintain polarity and movement without branched actin networks when confined, revealing a bleb-based protrusion mechanism distinct from the conventional actin-based one.

Light-based tuning of ligand half-life supports kinetic proofreading model of T cell activation

The paper directly tests the kinetic proofreading model of T cell activation by controlling ligand binding half-life with light, showing that lifetime, not occupancy, dominates activation.

A size-invariant bud-duration timer enables robustness in yeast cell size control

The paper investigates size control in yeast by blocking bud initiation, showing that size regulation occurs through a timer rather than a molecular sensor.