A. Takashima

Intracellular Tau Fragment Droplets Serve as Seeds for Tau Fibrils

This study shows that intracellular tau droplets form via microtubule collapse and act as seeds for tau fibrils, linking droplet formation to neurofibrillary tangle development in Alzheimer's disease.

Inducing aggresome and stable tau aggregation in Neuro2a cells with an optogenetic tool.

This paper introduces OptoTau, an optogenetic tool that induces different tau aggregation forms in Neuro2a cells based on blue light exposure patterns.

Extensive distribution of β-1,2-glucanases: finding of new glycoside hydrolase families of β-1,2-glucanases

The paper identifies three new glycoside hydrolase families of β-1,2-glucanases and reveals their functional and structural relationships within a superfamily.

An mRNA-LNP-based Lassa virus vaccine induces protective immunity in mice

This study shows that mRNA-LNP vaccines against Lassa virus protect mice from lethal infection, inducing strong CD8+ T cell responses without significant antibody production.

Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents

This paper develops a passive head motion system to simulate mechanical accelerations from treadmill running in rodents and shows it activates 5-HT2A signaling in the prefrontal cortex.

Antihypertensive effect of brain-targeted mechanical intervention with passive head motion

Passive head motion reduces blood pressure in hypertensive rats and humans by decreasing AT1R expression in RVLM astrocytes through interstitial fluid shear stress.