Author

B. J. LaFleur

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

M. Jergovic· 3 shared C. P. Coplen· 2 shared D. Bhattacharya· 2 shared J. L. Uhrlaub· 2 shared J. Nikolich-Zugich· 2 shared M. Watanabe· 2 shared S. A. Sonar· 2 shared A. Krueger· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

M. Jergovic

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

T-cell cellular stress and reticulocyte signatures, but not loss of naive T lymphocytes, characterize severe COVID-19 in older adults

M. Jergovic, M. Watanabe, R. Bhat, C. P. Coplen, S. A. Sonar, R. Wong, Y. Castaneda, L. Davidson, M. Kala, R. C. Wilson, H. L. Twigg, K. Knox, H. E. Erickson, C. C. Weinkauf, C. Bime, , J. Z. Nikolich

The paper identifies T-cell stress and reticulocyte signatures as markers of severe COVID-19 in older adults, while showing naive T-cell decline is age-related, not disease-specific.

bioRxiv · Dec 21, 2022Immunology

An early decline in ETPs reflects reduced pre-thymic progenitors and altered signals from the thymus microenvironment

J. Srinivasan, A. Vasudev, H. J. Selden, E. Perez, B. J. LaFleur, S. A. Sinari, A. Krueger, E. R. Richie, L. I. R. Ehrlich

The paper shows that early T-cell progenitors decline by 3 months in mice due to reduced pre-thymic progenitors and diminished Notch signaling.

bioRxiv · Jan 18, 2022 · PreprintImmunology

Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging

S. A. Sonar, J. L. Uhrlaub, C. P. Coplen, G. D. Sempowski, J. A. Dudakov, M. R. M. van den Brink, B. J. LaFleur, M. Jergovic, J. Nikolich-Zugich

This study shows that skin-draining lymph nodes atrophy early in mice, leading to impaired immune function and reduced effector cell production in older age.

bioRxiv · Nov 22, 2021Immunology

Competent immune responses to SARS-CoV-2 variants in older adults following mRNA vaccination

M. Jergovic, J. L. Uhrlaub, M. Watanabe, C. M. Bradshaw, L. M. White, B. J. LaFleur, T. Edwards, R. Sprissler, M. Worobey, D. Bhattacharya, J. Nikolich-Zugich

This study shows older adults have robust cellular immunity and comparable neutralizing antibody responses to SARS-CoV-2 variants after mRNA vaccination.

bioRxiv · Jul 22, 2021 · PreprintImmunology