Author

W. Zhai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 1 Immunology· 1 Physiology· 1 Zoology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

H. Chen· 2 shared J. Chen· 2 shared Y. Chen· 2 shared A. Chung· 1 shared A. Guo· 1 shared A. Jacobsen Skanderup· 1 shared A. James· 1 shared A. N. Kaya· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersPhysiology

H. Chen

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Single-cell and spatial atlas of steatotic liver-related hepatocellular carcinoma

A. Prawira, H. Xu, W. Q. Leow, M. Otsuka, Z. Chen, M. Rahbari, S. N. Hazirah, M. Wasser, A. Chung, B. K. P. Goh, P. K.-H. Chow, S. Albani, J. Lee, T. Lim, W. Zhai, , V. Chew

This study characterizes the tumor microenvironment of steatotic liver-related hepatocellular carcinoma using single-cell and spatial transcriptomic analyses, identifying immunosuppressive features and Treg-CAF interactions linked to immunotherapy resistance.

bioRxiv · May 9, 2024 · PreprintImmunology

Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

H. Chen, L. Sun, L. Feng, X. Han, Y. Zhang, W. Zhai, Z. Zhang, M. Mulholland, W. Zhang, Y. Yin

This study shows intermittent fasting increases IL-22 production by intestinal ILC3s, promoting beigeing of white adipose tissue and improving metabolic health.

bioRxiv · Aug 29, 2023 · PreprintPhysiology

Gene expression plasticity followed by genetic change during colonization a high-elevation environment

H. She, Y. Hao, G. Song, X. Luo, F. Lei, W. Zhai, Y. Qu

The paper quantifies gene expression plasticity and genetic change in Eurasian Tree Sparrows during high-elevation colonization, showing plasticity is often reversed or reinforced through selection.

bioRxiv · Feb 20, 2023 · PreprintEvolutionary Biology

Small RNA profiling in Mycobacterium insights into stress adapt ability

Y. Chen, W. Zhai, K. Zhang, T. Zhu, L. Su, L. E. Bermudez, H. Chen, A. Guo

The paper identifies stress-responsive small RNAs in Mycobacteria, finding some are linked to lipid metabolism and virulence.

bioRxiv · Jul 9, 2021Zoology

Obtaining Spatially Resolved Tumor Purity Maps Using Deep Multiple Instance Learning In A Pan-cancer Study

M. U. Oner, J. Chen, E. Revkov, A. James, S. Y. Heng, A. N. Kaya, J. J. S. Alvarez, A. Takano, X. M. Cheng, T. K. H. Lim, D. S. W. Tan, W. Zhai, A. Jacobsen Skanderup, W.-K. Sung, H. K. Lee

This paper develops a deep multiple instance learning model to predict tumor purity from histopathology slides, showing spatial variation and improving sample selection for genomic analysis.

bioRxiv · Jul 8, 2021Cancer Biology

Preclinical Study: Sunitinib-suppressed MiR-452-5p Facilitates Renal Cancer Cell Invasion and Metastasis Through Modulating SMAD4/SMAD7/EMT Signals

W. Zhai, S. Li, J. Zhang, Y. Chen, J. Ma, W. Kong, D. Gong, J. Zheng, W. Xue, Y. Xu

This study identifies miR-452-5p as a key regulator of renal cancer metastasis, showing its upregulation and role in promoting invasion through SMAD4/SMAD7/EMT signaling.

bioRxiv · Mar 22, 2018Cancer Biology