Palmitoylation of gasdermin D directs its membrane translocation and pore formation in pyroptosis
A. Balasubramanian, L. Ghimire, A. Y. Hsu, H. Kambara, X. liu, T. Hasegawa, R. xu, M. Tahir, H. Yu, J. Lieberman, H. R. Luo
The paper identifies palmitoylation of GSDMD at Cys191/Cys192 as essential for its membrane translocation and pore-forming activity in macrophages.
bioRxiv · Feb 21, 2023 · PreprintImmunology