Author

P. Uppuluri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 8 Organism:C. elegans· 4 Assay:proteomics· 4 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Alqarihi· 7 shared S. Singh· 7 shared A. S. Ibrahim· 6 shared S. Filler· 4 shared J. E. Edwards· 3 shared A. Ibrahim· 2 shared M. R. Yeaman· 2 shared S. Alkhazraji· 2 shared

Activity by Year

2018-2022 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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7 shared papersMicrobiology

A. Alqarihi

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Niclosamide loaded Eudragit EPO nanoparticles show enhanced Candida biofilm penetration, trigger biofilm detachment and protect from mucosal candidiasis

Y. Sutar, S. Nabeela, S. Singh, A. Alqarihi, N. V. Solis, T. Gebremariam, S. Filler, A. Ibrahim, A. Date, P. Uppuluri

This study identifies Niclosamide as a drug that disrupts Candida biofilms and develops nanoparticles to enhance its efficacy against drug-resistant strains.

bioRxiv · Jun 2, 2022 · PreprintMicrobiology

An evolutionarily diverged mitochondrial protein controls biofilm growth and virulence in Candida albicans

Z. Mamouei, S. Singh, B. Lemire, Y. Gu, A. Alqarihi, S. Nabeela, D. Li, A. Ibrahim, P. Uppuluri

This study identifies orf19.2500 as a mitochondrial protein essential for biofilm growth, virulence, and drug resistance in Candida albicans, with unique evolutionary inserts.

bioRxiv · Sep 29, 2020Microbiology

GRP78 and Integrins Play Different Roles in Host Cell Invasion During Mucormycosis

A. Alqarihi, T. Gebremariam, Y. Gu, M. Swidergall, S. Alkhazraji, s. Soliman, V. Bruno, J. Edwards, S. Filler, P. Uppuluri, A. S. Ibrahim

This study identifies GRP78 and integrins as distinct host receptors for Rhizopus delemar invasion in nasal and alveolar epithelial cells, explaining differential mucormycosis susceptibility in DKA and hematologic malignancy patients.

bioRxiv · Apr 29, 2020Microbiology

Monoclonal IgM antibodies raised against Candida albicans Hyr1 provide cross-kingdom protection against Gram negative bacteria

E. G. Youssef, S. Alkhazraji, T. Ghebremariam, L. Zhang, S. Singh, N. Y. Yount, M. R. Yeaman, P. Uppuluri, A. S. Ibrahim

The paper shows monoclonal antibodies against Candida albicans Hyr1 protect against Gram-negative bacterial infections.

bioRxiv · Jul 1, 2019Immunology

NDV-3A vaccination protects mice from Candida albicans biofilm infection

A. Alqarihi, S. Singh, J. E. Edwards, A. S. Ibrahim, P. Uppuluri

NDV-3A vaccine protects mice from Candida albicans biofilm infection by inducing antibodies that block adherence, invasion, and dispersal of the fungus.

bioRxiv · Nov 19, 2018 · PreprintImmunology

The NDV-3A vaccine protects mice from multidrug resistant Candida auris infection

S. Singh, P. Uppuluri, A. Alqarihi, H. Elhassan, S. French, S. R. Lockhart, T. CHiller, J. E. Edwards, A. S. Ibrahim

This paper shows that the NDV-3A vaccine protects mice from lethal C. auris infections and enhances antifungal drug efficacy.

bioRxiv · Nov 12, 2018Microbiology

Alexidine dihydrochloride has broad spectrum activities against diverse fungal pathogens

Z. Mamouei, A. Alqarihi, S. Singh, S. Xu, M. Mansour, A. S. Ibrahim, P. Uppuluri

This study identifies Alexidine dihydrochloride as a broad-spectrum antifungal drug effective against multiple fungal pathogens and preformed biofilms.

bioRxiv · Oct 3, 2018Microbiology

Human Als3p Antibodies are Surrogate Markers of NDV-3A Vaccine Efficacy Against Recurrent Vulvovaginal Candidiasis

P. Uppuluri, S. Singh, A. Alqarihi, C. S. Schmidt, J. P. Hennessey, M. R. Yeaman, S. Filler, J. E. Edwards, A. S. Ibrahim

The paper evaluates anti-Als3p antibodies as surrogate markers for NDV-3A vaccine efficacy against recurrent vulvovaginal candidiasis by comparing vaccinated individuals with and without recurrence.

bioRxiv · May 17, 2018Immunology

Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence

N.-N. Liu, P. Uppuluri, A. Broggi, A. Besold, K. Ryman, H. Kambara, N. Solis, V. Lorenz, W. Qi, M. Acosta Zaldivar, S. N. Emami, B. Bao, D. An, F. Bonilla, M. Sola-Visner, , J. R. Koehler

This study shows that Pho84 in Candida albicans affects virulence by modulating oxidative stress through Sod3 and TORC1 pathways.

bioRxiv · May 11, 2018Microbiology

Candida albicans dispersed cells signify a developmental state distinct from biofilm and planktonic phases

P. Uppuluri, M. Acosta Zakvidar, M. Anderson, M. Dunn, J. Berman, J. L. Lopez Ribot, J. Koehler

The paper identifies dispersed Candida albicans cells as a distinct developmental state with unique transcriptomic features compared to biofilm and planktonic phases.

bioRxiv · Feb 1, 2018Microbiology