T. Hasegawa

Global trends in biodiversity and ecosystem services from 1900 to 2050

The paper assesses historical and future trends in biodiversity and ecosystem services from 1900 to 2050, finding that biodiversity and regulating services have decreased while provisioning services increased, with climate change expected to worsen future losses.

Development of a new genotype-phenotype linked antibody screening system

This paper develops a new antibody screening system using a Golden Gate-based dual-expression vector to rapidly isolate high-affinity cross-reactive antibodies from immunized mice.

Revealing the spatial characteristics of rice heat exposure in Japan through panicle temperature analysis

This study analyzes panicle temperature trends in Japan over 45 years to assess rice heat exposure and its implications for breeding and crop management.

Mapping adipocyte interactome networks by HaloTag enrichment mass-spectrometry

The paper introduces HaloMS, a high-throughput method for mapping protein interactions in adipocytes, identifying new transcription factor complexes and networks.

Distinct adrenal gland macrophages regulate corticosteroid production

This study identifies two distinct adrenal macrophage subsets in mice and shows that foamy macrophages regulate corticosteroid production through cholesterol accumulation.

Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

The paper shows extensive genomic overlap between Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis, including shared genes and recombination events, with implications for vaccine development.

Time-, tissue- and treatment-associated heterogeneity in tumour-residing migratory DCs

This study identifies heterogeneous tumor-residing migratory dendritic cells (mRegDCs) that show distinct transcriptional and functional profiles, impacting anti-tumor immune responses.

Effectiveness of heat tolerance rice cultivars in preserving grain appearance quality under high temperatures - A meta-analysis

This meta-analysis quantifies how heat-tolerant rice cultivars reduce chalky grain percentage under high temperatures, showing a 66% point increase in CG for low HTR cultivars with rising TaHD.

Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen

The paper shows that cytotoxic CD4+ T cells eliminate senescent fibroblasts by targeting HCMV-gB antigen expressed on these cells, reducing their accumulation in old skin.

Palmitoylation of gasdermin D directs its membrane translocation and pore formation in pyroptosis

The paper identifies palmitoylation of GSDMD at Cys191/Cys192 as essential for its membrane translocation and pore-forming activity in macrophages.

Nitrogen uptake pattern of dry direct-seeding rice and its contribution to yield in a cool temperate climate

This study compares nitrogen uptake patterns and yield contributions between dry direct-seeding rice and transplanted rice in a cool temperate climate, finding lower yield in DDSR due to reduced nitrogen use efficiency.

A global dataset for the projected impacts of climate change on four major crops

The paper compiles a global dataset of climate change impacts on four crops using existing studies and new literature, providing yield projections under different emission scenarios.

Visualization of lake succession as indicated by macrophyte species composition and trophic levels in lakes subdivided by volcanic eruption at Akan Caldera, Hokkaido, Japan

The paper uses lake size and watershed area ratios to predict trophic levels and macrophyte composition in lakes formed by volcanic eruptions, revealing a pattern of hydrarch succession.

Trophic transfer of microplastics enhances tissue accumulation of chemical additives in fish

This study compares chemical accumulation in fish from direct microplastic exposure versus indirect exposure through prey, finding higher concentrations from prey-mediated ingestion.

Canopy micrometeorology monitoring in diverse climates innovatively improves the evaluation heat-induced sterility of rice under climate change

This study evaluates heat-induced sterility in rice using canopy micrometeorology data across diverse climates, showing that panicle temperature can accurately predict sterility rates.

OsNLP4 is required for nitrate assimilation gene expressions and nitrate-dependent growth in rice

The study identifies OsNLP4 as essential for nitrate assimilation gene expression and nitrate-dependent growth in rice.

A unified simulation model for understanding the diversity of cancer evolution

This study develops a unified simulation model to analyze cancer evolution dynamics and identifies conditions under which different evolutionary processes drive tumor growth.

Comprehensive Analysis of Indels in Whole-genome Microsatellite Regions and Microsatellite Instability across 21 Cancer Types

The paper analyzes microsatellite mutations across 21 cancer types, identifies MSI cancers, and finds factors influencing mutation rates and functional impacts.

A protocol for an intercomparison of biodiversity and ecosystem services models using harmonized land-use and climate scenarios

This paper describes a protocol for comparing biodiversity and ecosystem services models using harmonized land-use and climate scenarios to assess future impacts and model uncertainties.

Systematic identification of cancer-specific MHC-binding peptides with RAVEN

The paper introduces RAVEN, a software tool that identifies cancer-specific genes encoding MHC-affine peptides from gene expression data, validated across 50 cancer types.

Spatial and temporal translocation of PKCα in single endothelial cell in response to focal mechanical stimulus

The paper investigates PKCα translocation in endothelial cells under mechanical stress, finding biphasic movement requiring Ca2+ and DAG for initial translocation and MS channels for secondary translocation.