Author

H. Knochelmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

B. A. Aksoy· 2 shared C. M. Paulos· 2 shared G. B. Lesinski· 2 shared A. B. Farris· 1 shared A. C. Cole· 1 shared A. N. Ruggieri· 1 shared A. S. Smith· 1 shared A. Smith· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

B. A. Aksoy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The degree of T cell stemness differentially impacts the potency of adoptive cancer immunotherapy in a Lef-1 and Tcf-1 dependent manner.

G. O. Rangel Rivera, C. J. Dwyer, H. Knochelmann, A. S. Smith, B. A. Aksoy, A. C. Cole, M. M. Wyatt, J. E. Thaxton, G. B. Lesinski, C. M. Paulos

This study shows that varying levels of PI3Kδ pathway inhibition affect T cell stemness, with higher stemness improving cancer immunotherapy outcomes in multiple tumor models.

bioRxiv · Mar 8, 2023 · PreprintImmunology

Discovering tumor-reactive T-cell receptors through single-cell sequencing of tumor-infiltrating lymphocytes

E. Gottschalk, B. A. Aksoy, P. Aksoy, M. Swiderska-Syn, C. Mart, L. Macpherson, M. Romeo, A. Smith, H. Knochelmann, C. Paulos, C. Timmers, J. Wrangle, M. P. Rubinstein, J. Hammerbacher

The paper uses single-cell sequencing of tumor-infiltrating lymphocytes to identify and validate novel tumor-reactive T-cell receptors in a mouse model.

bioRxiv · Nov 30, 2021 · PreprintImmunology

Dual blockade of IL-6 and CTLA-4 regresses pancreatic tumors in a CD4+ T cell-dependent manner.

M. B. Ware, C. McQuinn, M. Y. Zaidi, H. Knochelmann, T. A. Mace, Z. Chen, C. Zhang, M. R. Farren, A. N. Ruggieri, J. Bowers, R. Shakya, A. B. Farris, G. Young, W. E. Carson, B. El-Rayes, , G. B. Lesinski

This study shows dual IL-6 and CTLA-4 blockade regresses pancreatic tumors via CD4+ T cells and CXCR3-dependent mechanisms.

bioRxiv · Feb 7, 2020 · PreprintCancer Biology