Author

C. J. Dwyer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. S. Smith· 3 shared C. M. Paulos· 3 shared G. O. Rangel Rivera· 3 shared M. M. Wyatt· 3 shared A. M. Rivera-Reyes· 2 shared D. M. Neskey· 2 shared H. M. Knochelmann· 2 shared J. E. Thaxton· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersImmunology

A. S. Smith

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3 papers

Recent·Most cited

The degree of T cell stemness differentially impacts the potency of adoptive cancer immunotherapy in a Lef-1 and Tcf-1 dependent manner.

G. O. Rangel Rivera, C. J. Dwyer, H. Knochelmann, A. S. Smith, B. A. Aksoy, A. C. Cole, M. M. Wyatt, J. E. Thaxton, G. B. Lesinski, C. M. Paulos

This study shows that varying levels of PI3Kδ pathway inhibition affect T cell stemness, with higher stemness improving cancer immunotherapy outcomes in multiple tumor models.

bioRxiv · Mar 8, 2023 · PreprintImmunology

B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity

A. S. Smith, H. M. Knochelmann, M. M. Wyatt, G. O. Rangel Rivera, A. M. Rivera-Reyes, C. J. Dwyer, D. M. Neskey, M. P. Rubinstein, B. Liu, J. E. Thaxton, E. Bartee, C. M. Paulos

This study shows that CpG-mediated expansion with B cells enhances CD8+ T cell tumor immunity by inducing a unique proteomic signature and specific surface markers.

bioRxiv · Mar 16, 2021Immunology

Modeling ex vivo tumor-infiltrating lymphocyte expansion from established solid malignancies

H. M. Knochelmann, A. M. Rivera-Reyes, M. M. Wyatt, A. S. Smith, R. Chamness, C. J. Dwyer, M. Bobian, G. O. Rangel Rivera, J. D. Horton, M. Lilly, M. P. Rubinstein, D. M. Neskey, C. M. Paulos

The paper expands murine tumor-infiltrating lymphocytes ex vivo in IL-2 and compares their phenotypes to human TILs from oral cavity cancer patients.

bioRxiv · Feb 4, 2021Immunology