T. Mehlman

An expanded view of ligandability in the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data

The paper reanalyzes crystallographic data to identify new ligand-bound states of PTP1B, revealing hidden binding sites and allosteric effects.

High-energy demand and nutrient exhaustion in MTCH2 knockout cells

This study shows that MTCH2 deletion increases energy demand and metabolic imbalance in cells, which inhibits adipocyte differentiation.

High-resolution double vision of the archetypal protein tyrosine phosphatase

This study presents the highest-resolution crystal structure of apo PTP1B, revealing conformational heterogeneity and highlighting how mutations enhance local dynamics.

A conserved family of immune effectors cleaves cellular ATP upon viral infection

This study identifies a conserved family of immune effectors that degrade ATP and dATP during viral infection, halting phage propagation and suggesting a conserved innate immune strategy across life.

The differential regulation of placenta trophoblast bisphosphoglycerate mutase in fetal growth restriction: preclinical study in mice and observational histological study of human placenta.

This study investigates the role of placental BPGM in fetal growth restriction using mouse models and human placental analysis, finding altered BPGM expression and 2,3 BPG levels in hypoxic conditions.

Bringing BOS to light: Uncovering the key enzyme in the biosynthesis of the neurotoxin β-ODAP in Grass Pea (Lathyrus sativus L.)

The paper identifies the enzyme BOS responsible for β-ODAP biosynthesis in grass pea, revealing its structure and function after over 50 years of research.