Author

H. Al-Akhrass

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

J. Ivaska· 3 shared A. Disanza· 1 shared A. Padzik· 1 shared A. S. A. Poulsen· 1 shared C. Sommer· 1 shared E. Peuhu· 1 shared E.-M. Vesilahti· 1 shared G. Jacquemet· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

J. Ivaska

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Sortilin-related receptor is a druggable therapeutic target in breast cancer

H. Al-Akhrass, M. Pietilä, J. Lilja, E.-M. Vesilahti, J. M. Anttila, H. M. Haikala, P. M. Munne, J. Klefström, E. Peuhu, J. Ivaska

This study shows that targeting SorLA with a monoclonal antibody can overcome HER2 resistance in breast cancer, both in vitro and in vivo.

bioRxiv · Mar 9, 2021Cancer Biology

Cargo-specific recruitment in clathrin and dynamin-independent endocytosis

P. Moreno-Layseca, N. Z. Jäntti, R. Godbole, C. Sommer, G. Jacquemet, H. Al-Akhrass, P. Kronqvist, R. E. Kallionpaa, L. Oliveira-Ferrer, P. Cervero, S. Linder, M. Aepfelbacher, J. Rae, R. G. Parton, A. Disanza, , J. Ivaska

The paper identifies swiprosin-1 as a cargo-specific adaptor for the CG-pathway, showing its role in integrin internalization and breast cancer progression.

bioRxiv · Oct 5, 2020Cell Biology

A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance

H. Al-Akhrass, J. R. W. Conway, A. S. A. Poulsen, I. Paatero, J. Kaivola, A. Padzik, O. M. Andersen, J. Ivaska

This study identifies a feed-forward loop involving SorLA and HER3 that enhances heregulin response and neratinib resistance in breast cancer.

bioRxiv · Jun 10, 2020Cancer Biology