Author

H. M. Knochelmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 5 Research Focus:cancer & tumor microenvironment· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. M. Paulos· 5 shared M. M. Wyatt· 5 shared G. O. Rangel Rivera· 4 shared A. S. Smith· 3 shared M. P. Rubinstein· 3 shared A. M. Rivera-Reyes· 2 shared C. J. Dwyer· 2 shared D. M. Neskey· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersImmunology

C. M. Paulos

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5 papers

Recent·Most cited

Distinct host preconditioning regimens differentially impact the antitumor potency of adoptively transferred Th17 cells.

M. C. Wittling, H. M. Knochelmann, M. M. Wyatt, G. O. Rangel Rivera, A. C. Cole, G. B. Lesinski, C. M. Paulos

This study compares the effects of two host preconditioning methods on the antitumor activity of adoptively transferred Th17 cells, finding that total body irradiation enhances their efficacy more than chemotherapy.

bioRxiv · Dec 18, 2023Cancer Biology

Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cell therapy

M. M. Wyatt, L. W. Huff, M. H. Nelson, L. R. Neal, A. R. Medvec, G. O. Rangel Rivera, A. S. Smith, A. M. Rivera Reyes, H. M. Knochelmann, J. L. Riley, G. B. Lesinski, C. M. Paulos

This study shows that reducing TCR and co-stimulation signal strength in Th17 cell manufacturing enhances their metabolic fitness and antitumor efficacy in mesothelioma models.

bioRxiv · Oct 28, 2022Immunology

B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity

A. S. Smith, H. M. Knochelmann, M. M. Wyatt, G. O. Rangel Rivera, A. M. Rivera-Reyes, C. J. Dwyer, D. M. Neskey, M. P. Rubinstein, B. Liu, J. E. Thaxton, E. Bartee, C. M. Paulos

This study shows that CpG-mediated expansion with B cells enhances CD8+ T cell tumor immunity by inducing a unique proteomic signature and specific surface markers.

bioRxiv · Mar 16, 2021Immunology

Modeling ex vivo tumor-infiltrating lymphocyte expansion from established solid malignancies

H. M. Knochelmann, A. M. Rivera-Reyes, M. M. Wyatt, A. S. Smith, R. Chamness, C. J. Dwyer, M. Bobian, G. O. Rangel Rivera, J. D. Horton, M. Lilly, M. P. Rubinstein, D. M. Neskey, C. M. Paulos

The paper expands murine tumor-infiltrating lymphocytes ex vivo in IL-2 and compares their phenotypes to human TILs from oral cavity cancer patients.

bioRxiv · Feb 4, 2021Immunology

Identification of human CD4+ T cell populations with distinct antitumor activity

M. H. Nelson, H. M. Knochelmann, S. R. Bailey, L. W. Huff, J. S. Bowers, K. Majchrzak, M. M. Wyatt, M. P. Rubinstein, S. Mehrotra, M. I. Nishimura, K. Armeson, P. G. Giresi, M. J. Zilliox, H. E. Broxmeyer, C. M. Paulos

The paper identifies human CD4+ T cell populations with distinct antitumor activity, showing CD26high T cells are epigenetically and transcriptionally different from Th17 cells and are more effective in tumor therapy.

bioRxiv · Dec 31, 2019Immunology