Author

K. Rosenke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Ecology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 10 Approach:experimental assay· 9 Organism:rat· 5 Organism:mouse· 4 Research Focus:drug response / drug discovery· 2 Organism:non-human primate· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

H. Feldmann· 9 shared A. Okumura· 7 shared F. Feldmann· 6 shared K. Meade-White· 6 shared M. Jarvis· 6 shared C. Shaia· 4 shared G. Saturday· 4 shared J. Lovaglio· 4 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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Curved chords = mutual co-authorship

9 shared papersMicrobiology

H. Feldmann

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Rectal and vaginal challenge with mpox virus increases virus dissemination and contact transmission compared to skin challenge in the multimammate rat (Mastomys natalensis)

J. R. Port, J. C. Riopelle, S. G. Smith, L. Myers, M. C. Lewis, S. Gallogly, A. Okumura, J. E. Schukz, R. Rosenke, J. Prado-Smith, A. Carmody, S. Bane, B. J. Smith, G. Saturday, H. Feldmann, , V. J. Munster

This study shows that rectal and vaginal mpox virus inoculation in rats leads to more virus shedding and contact transmission compared to skin inoculation.

bioRxiv · May 7, 2023 · PreprintMicrobiology

SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta

N. van Doremalen, M. Singh, T. Saturday, K. C. Yinda, L. Perez-Perez, W. F. Bohler, Z. Weishampel, M. Lewis, J. Schulz, B. Williamson, K. Meade-White, S. Gallogly, A. Okumura, F. Feldmann, J. Lovaglio, , K. Rosenke

This study compares disease severity and viral load in rhesus macaques infected with SARS-CoV-2 Delta, Omicron BA.1, and BA.2 variants, finding Omicron variants cause less severe disease with lower viral loads.

Science Advances · Nov 16, 2022Peer-reviewedMicrobiology

Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques

K. Rosenke, M. Lewis, F. Feldmann, E. Bohrnsen, B. Schwarz, A. Okumura, W. F. Bohler, J. Callison, C. Shaia, C. Bosio, J. Lovaglio, G. Saturday, M. Jarvis, H. Feldmann

The combination of molnupiravir and nirmatrelvir inhibits SARS-CoV-2 replication and shedding more effectively than individual treatments in the rhesus macaque model.

bioRxiv · Sep 3, 2022Microbiology

Molnupiravir (MK-4482) is efficacious against Omicron and other SARS-CoV-2 variants in the Syrian hamster COVID-19 model

K. Rosenke, A. Okumura, M. C. Lewis, F. Feldmann, K. Meade-White, W. F. Bohler, A. Griffin, R. Rosenke, C. Shaia, M. Jarvis, H. Feldmann

MK-4482 inhibits replication of multiple SARS-CoV-2 variants of concern, including Omicron, in the Syrian hamster model.

bioRxiv · Feb 22, 2022 · PreprintMicrobiology

Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine

D. W. Hawman, K. Meade-White, C. Clancy, J. Archer, T. Hinkley, S. Leventhal, D. Rao, A. Stamper, M. Lewis, R. Rosenke, K. Krieger, S. Randall, A. P. Khandhar, L. Hao, T.-Y. Hsiang, , J. Erasmus

bioRxiv · Jan 31, 2022Microbiology

UK B.1.1.7 variant exhibits increased respiratory replication and shedding in nonhuman primates

K. Rosenke, F. Feldmann, A. Okumura, F. Hansen, T.-L. Tang-Huau, K. Meade-White, B. Kaza, B. J. Smith, P. W. Hanley, J. Lovaglio, M. Jarvis, C. Shaia, H. Feldmann

This study compares the respiratory replication and shedding of SARS-CoV-2 D614G and B.1.1.7 variants in African green monkeys, finding increased respiratory replication for B.1.1.7 but no disease enhancement.

bioRxiv · Jun 11, 2021Microbiology

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers.

K. Rosenke, S. Leventhal, H. Moulton, S. Hatlevig, D. Hawman, H. Feldmann, D. A. Stein

This study evaluates peptide-conjugated morpholino oligomers (PPMO) against SARS-CoV-2 in Vero cells, showing significant viral titer reduction without toxicity.

bioRxiv · Sep 29, 2020Microbiology

Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection

K. Rosenke, K. Meade-White, M. C. Letko, C. Clancy, F. Hansens, Y. Liu, A. Okumura, T.-L. Tang-Huau, R. Li, G. Saturday, F. Feldmann, D. Scott, Z. Wang, V. Munster, M. Jarvis, H. Feldmann

The paper shows Syrian hamsters are highly susceptible to SARS-CoV-2, making them a suitable model for developing countermeasures against COVID-19.

bioRxiv · Sep 25, 2020Microbiology

Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2

K. Rosenke, M. Jarvis, F. Feldmann, B. Schwarz, A. Okumura, J. Lovaglio, G. Saturday, P. Hanley, K. Meade-White, B. Williamson, F. Hansen, L. Perez-Perez, S. Leventhal, T.-L. Tang-Huau, M. Nason, , H. Feldmann

This study shows hydroxychloroquine does not reduce SARS-CoV-2 replication or improve clinical outcomes in hamsters or macaques.

bioRxiv · Jun 10, 2020 · PreprintPharmacology & Toxicology

Bayesian estimation of Lassa virus epidemiological parameters: implications for spillover prevention using wildlife vaccination

S. L. Nuismer, C. H. Remien, A. Basinski, T. Varrelman, N. Layman, K. Rosenke, B. Bird, M. Jarvis, P. Barry, E. Fichet-Calvet

This paper develops a Bayesian method to estimate Lassa virus epidemiological parameters and evaluates rodent vaccination efficacy using simulated and real data from Guinea.

bioRxiv · Nov 13, 2019Ecology