Author

M. N. Pollak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:cryo-EM· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

A. Gariepy· 1 shared A. O. Donayo· 1 shared B. P. Leitner· 1 shared D. Avizonis· 1 shared D. G. Jovin· 1 shared G. Bridon· 1 shared H. R. Bridges· 1 shared I. Chung· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

A. Gariepy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural Basis of Mammalian Respiratory Complex I Inhibition by Medicinal Biguanides

H. R. Bridges, J. N. Blaza, Z. Yin, I. Chung, M. N. Pollak, J. Hirst

This study identifies how biguanides inhibit respiratory complex I by binding in the quinone channel and causing a chaotropic effect.

bioRxiv · Aug 9, 2022Biochemistry

Gene Expression and Tracer-Based Metabolic Flux Analysis Reveals Tissue-Specific Metabolic Scaling in vitro, ex vivo, and in vivo

N. D. Akingbesote, B. P. Leitner, D. G. Jovin, R. Desrouleaux, W. Zhu, Z. Li, M. N. Pollak, R. J. Perry

The paper uses gene expression and metabolic flux analysis to show that metabolic scaling occurs in multiple pathways across species, not just oxygen consumption.

bioRxiv · Mar 2, 2022Physiology

Repression of LKB1 by miR-17~92 sensitizes MYC-dependent lymphoma to biguanide treatment

S. Izreig, A. Gariepy, A. O. Donayo, G. Bridon, D. Avizonis, R. D. Sheldon, R. Laister, M. D. Minden, N. A. Johnson, K. S. Williams, M. S. Rudoltz, T. F. Duchaine, S. Yoo, M. N. Pollak, R. G. Jones

The paper shows that miR-17~92 expression in Myc+ tumors increases sensitivity to biguanide treatment by disrupting bioenergetic stability in lymphoma cells.

bioRxiv · Dec 20, 2019Cancer Biology