J. N. Blaza

A Protein Blueprint of the Diatom CO2-Fixing Organelle

The paper identifies a protein interaction network in the diatom pyrenoid, revealing a structural shell critical for CO2 fixation and suggesting convergent evolution with prokaryotic carboxysomes.

Cryo-EM structure of the CDK2-cyclin A-CDC25A complex

The paper presents the cryo-EM structure of the CDK2-cyclin A-CDC25A complex, revealing key interactions and suggesting potential binding partners for CDC25A.

Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade

This study shows that mitochondrial DNA mutations in complex I genes drive aerobic glycolysis, enhancing immune checkpoint blockade response in tumors.

Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum

This paper reports the cryo-EM structure and kinetics of sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum, revealing its cofactor usage and catalytic mechanism in sulfolactate synthesis.

Structural Basis of Mammalian Respiratory Complex I Inhibition by Medicinal Biguanides

This study identifies how biguanides inhibit respiratory complex I by binding in the quinone channel and causing a chaotropic effect.

Structure of the deactive state of mammalian respiratory complex I

This study determines the structure of the deactive state of Bos taurus complex I using cryo-EM, revealing structural changes associated with the transition from active to deactive states.