Author

H. Sadek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 4 Research Focus:development & morphogenesis· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1

Frequent Co-Authors

F. Xiao· 2 shared N. Lam· 2 shared N. U. N. Nguyen· 2 shared S. Li· 2 shared W. Kimura· 2 shared A. Cardoso· 1 shared A. Elnwasany· 1 shared A. H. Pereira· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

F. Xiao

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A latent cardiomyocyte regeneration potential in the human heart

W. Derks, J. Rode, S. Collin, F. Rost, P. Heinke, A. Hariharan, L. Pickel, I. Simonova, E. Lazar, E. Graham, R. Jashari, M. Andrae, A. Jeppsson, M. Salehpour, K. Alkass, , O. Bergmann

This study shows that cardiomyocyte renewal is significantly reduced in end-stage heart failure but increases in patients with improved cardiac function from left ventricle support devices.

bioRxiv · Sep 14, 2023Cell Biology

Angiocrine IGFBP3 Spatially Coordinates IGF Signaling During Neonatal Cardiac Regeneration

S. Ali, W. Elhelaly, N. U. N. Nguyen, S. Li, I. Menendez-Montes, Z. Wang, M. Cui, A. Elnwasany, F. Xiao, S. Thet, N. Lam, A. Cardoso, A. H. Pereira, M. Goodarzi, M. Kinter, , H. Sadek

The paper identifies IGFBP3 as a secreted protein that spatially coordinates IGF signaling to promote neonatal cardiac regeneration.

bioRxiv · Sep 16, 2021Cell Biology

Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis

F. Xiao, N. Lam, P. Wang, S. Li, D. Canseco, W. Kimura, X. Luo, N. U. N. Nguyen, W. El Helaly, R. Singh, S. Sadayappan, M. Kanchwala, C. Xing, R. Hajjar, J. Hill, H. Sadek

This study identifies adducin as a regulator of sarcomere disassembly during cardiomyocyte mitosis, showing phosphorylation of a short isoform induces disassembly in neonatal cardiomyocytes.

bioRxiv · Dec 24, 2020Cell Biology

Deep Learning Identifies Cardiomyocyte Nuclei in Murine Tissue with High Precision

S. R. Ali, D. Nguyen, B. Wang, S. Jiang, H. Sadek

The paper develops a deep learning model to identify cardiomyocyte nuclei in mouse heart tissue using image segmentation and immunostaining, achieving high sensitivity and specificity.

bioRxiv · Jan 10, 2020Cell Biology